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Surgical Specialties

Isaac Samuel, MD

Associate Professor
Department of Surgery
Director, UI Obesity Surgery Program
Division of Gastrointestinal, Minimally Invasive and Bariatric Surgery
isaac-samuel@uiowa.edu
Office Telephone: 319-384-7359

Gastrointestinal, Minimally Invasive and Bariatric Clinic
Telephone: 319-356-4060

Medical School:

• 1981, Bangalore Medical College, Bangalore University, Karnataka State, India

Post-graduate Studies: 1982-1984

• Internship & Surgical junior residencies: Bangalore (1981-1983) and Tiruvella (1983-1984), India

Lecturer: 1985-1986

• Department of Anatomy, St John’s Medical College, Bangalore University, India

Higher Surgical Studies: 1987-1991

• Fellow of the Royal College of Surgeons (FRCS), UK 1989
• Registrar in Surgery, Leeds General Infirmary, Leeds University, Leeds, UK 1987-1989
• Registrar in Surgery, St Thomas’ Hospital, University of London, UK 1989-1991

Research Fellowship: 1991-1994

• Department of Surgery, Northwestern University Medical School, Chicago, IL

Surgical Residency: 1994-99

• General Surgery, Department of Surgery, Rush Medical College,
  Rush University, Chicago, IL

Post-Graduate Education

• Laparoscopic and bariatric surgery training: 2000-2002
  University of Iowa Obesity Surgery Program
  Proctored training under Dr. James Maher, Dr. Cornelius Doherty and Dr. Edward Mason

Certification:

• American Board of Surgery: Board Certified (General Surgery) April 11, 2000

Licensure:

• Iowa, Illinois, California

Honors and Awards:

• NIH R01 Grant Award, 2008-2013, NIDDK, NIH, Bethesda, MD ($1,455,625)
• American Recovery and Reinvestment Act 2009 Supplemental Award to NIH R01 2009-11 ($200,000).
• VA Merit Review Award, 2008-2010, Biomedical Laboratory Research & Development Service, Department of Veterans Affairs, Washington, D.C.
• Bariatric Surgery, 2007, American Society for Metabolic and Bariatric Surgery National Center of Excellence
• NIH Career Award (2003-2007) NIH K08 Mentored Clinical Scientist Development Award (National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD)
• ACS Faculty Research Fellowship Award (2003-2005) American College of Surgeons
• National Pancreas Foundation Research Award (2003-2004) National Pancreas Foundation
• Carver Collaborative Pilot Grant Award (2002) University of Iowa Carver College of Medicine
• Florence Lindsay Young Investigator Award (2001) University of Iowa Carver College of Medicine
• CIFRE Research Award (2000) Central Investment Fund for Research Enhancement, Office of the Vice-President for Research, University of Iowa
• Top 20 Promising Young Investigators (1993-95) Society for Surgery of the Alimentary Tract and Ross Laboratories 8th, 9th, and 10th Annual Residents and Fellows Research Conferences

Outstanding achievements:

• “Blue Distinction Center for Bariatric Surgery”, 2006, National BCBS Association
• Wellmark/Blue Cross Blue Shield of Iowa Bariatric Surgery Center of Excellence (2005)
• UIHC New Clinical Initiative 2005-2008: Multi-disciplinary Bariatric Surgery Program, Director of Program and Chairman of Task Force

Memberships in Professional Organizations:

• Royal College of Surgeons & Physicians, Glasgow (1989)
• American Pancreatic Association (1989)
• American Gastroenterological Association (2000)
• Association of Academic Surgeons (2001)
• American College of Surgeons, Full Fellowship (2002)
• Iowa Medical Society (2003)
• Association of VA Surgeons (2003)
• Society for Surgery of the Alimentary Tract (2004)
• American Society for Metabolic and Bariatric Surgery (2005)

Selected Recent Publications:

• Samuel I, Zaheer S, Fisher RA, Zaheer A. Cholinergic receptor induction and JNK activation in acute pancreatitis. Am J Surg. 2003 Nov;186(5):569-74.
• Ishigami K, Decker GT, Bolton-Smith JA, Samuel I, Wilson SR, Brown BP. Case Report – “Ruptured Splenic Abscess: a cause of pneumoperitoneum in a patient with AIDS”. Emergency Radiology 2003;10:163-165.
• Ishigami K, Sato Y, Khanna G, Samuel I, Dahmoush L. Case-report - "Gas-forming abdominal wall abscess: unusual manifestation of perforated retroperitoneal appendicitis extending through the superior lumbar triangle". Emergency Radiology 2004; 10:207-209.
• Samuel I, Zaheer S, Yorek M, Nelson JJ, Zaheer A. (Rapid Communication) CCK-A receptor induction and p38MAPK and NF-kB activation in acute pancreatitis. Pancreatology 2004;4: 49-56.
• Samuel I, Toriumi Y, Zaheer A, Joehl RJ. Mechanism of acute pancreatitis exacerbation by enteral bile-pancreatic juice exclusion (Rapid Communication) Pancreatology 2004 Aug 27;4(6):527-532).
• Samuel I, Zaheer A, Zaheer S, Fisher R. Bile-pancreatic juice exclusion increases cholinergic M3 and CCK-A receptor expression and IL-6 production in ligation-induced acute pancreatitis Am J Surg. 2004 Nov;188(5):511-5.
• Samuel I, Zaheer S, Zaheer A. Bile-pancreatic juice exclusion increases p38 MAPK activation and TNF-α production in ligation-induced acute pancreatitis in rats. (Rapid Communication) Pancreatology 2005;5(1):20-6.
• Samuel I, Chaudhary A, Fisher R, Joehl RJ. Exacerbation of acute pancreatitis by combined cholinergic stimulation and duct obstruction. American Journal of Surgery 2005;190(5):721-4.
• Johnson JM, Maher JW, Samuel I, Heitshusen D, Doherty C, Downs RW. Effects of gastric bypass procedures on bone mineral density, calcium, parathyroid hormone and vitamin D. Journal of Gastrointestinal Surgery 2005;9(8):1106-11.
• Samuel I, Yorek M, Zaheer A, Fisher R. Bile-Pancreatic Juice Exclusion Activates Akt/NF-kB Pathway and Chemokine Production in Ligation-Induced Acute Pancreatitis. Journal of Gastrointestinal Surgery 2006;10(7):950-9.
• Samuel I, Mason EE, Renquist KE, Huang Y, Zimmerman MB, Jamal M. Bariatric Surgery Trends: An 18-Year Report from the International Bariatric Surgery Registry. American Journal of Surgery 2006; 192:657-662.
• Samuel I, Zaheer A, Fisher R. In vitro evidence for role of ERK, p38 and JNK in acinar cell TNF and IL-1 production. Journal of Gastrointestinal Surgery 2006;10(10):1376-1383.
• Mason EE, Renquist KE, Huang Y, Jamal M, Samuel I. Cause of 30-day obesity surgery mortality: with emphasis on bypass obstruction. Obesity Surgery 2007;17(1):9-14).
• Nishie A, Brown B, Barloon T, Kuehn D, Samuel I. Routine upper gastrointestinal contrast study after laparoscopic Roux-en-Y gastric bypass: comparison of radiological findings with short-term results. Obesity Surgery 2007; 17(9):1183-1188.
• Meyerholz DK, Samuel I. Morphological characteriztion of early ligation-induced acute pancreatitis in rats. American Journal of Surgery 2007; 194(5):652-658.
• Samuel I, Tephly L, Williard DE, Carter AB. Enteral exclusion increases MAP kinase activation & cytokine production in a model of gallstone pancreatitis. Pancreatology 2008, 31;8(1):6-14.
• Samuel I. Evidence-based surgical hypothesis – Bile and pancreatic juice exclusion activates stress kinases and exacerbates gallstone pancreatitis. Surgery 2008:143:434-440.
• Meyerholz DK, Williard DE, Gritmann A, Samuel I. Murine pancreatic duct ligation induces stress kinase activation, acute pancreatitis, and acute lung injury. American Journal of Surgery 2008, 196(5):675-82.

Chapters:

• Samuel I, Staren ED, Prinz RA. Diagnosis and management of primary hyperparathyroidism. In: Staren ED, Prinz RA, eds. Handbook of endocrine surgery. Landes Bioscience Publishers, Georgetown, Texas, 2000.

• Samuel I, Foster GS, Millikan KW. Liver masses. In: Saclarides T, Millikan KW, Godelas D, eds. Surgical oncology: An algorithmic approach. Springer-Verlag, New York, NY, 2003.

• Samuel I. Laparoscopic hiatal hernia repair. In: Scott-Conner C, ed. Operative anatomy, 2nd edition. Lippincott Williams & Wilkins, Philadelphia, PA, 2003.

• Samuel I, Maher JW. Cholelithiasis and cholecystitis. In:Conn’s Current Therapy 2005.

• Samuel I, Joehl RJ. Chronic pancreatitis. In: Surgery - Scientific Principles and Practice, 4th Edition, Eds. Mulholland, Lillemoe, Doherty, Maier, Upchurch. Lippincott Williams & Wilkins, Philadelphia, PA, 2006.

• Samuel I, Millikan KW. The liver mass. In: Saclarides T, Millikan KW, eds. Common surgical diseases – an algorithmic approach. 2nd Edition, Springer-Verlag, New York, New York 2008.

• Samuel I. Laparoscopic hiatal hernia repair. In: Scott-Conner C, ed. Operative anatomy, 3rd edition. Lippincott Williams & Wilkins, Philadelphia, PA, 2009.

Review Panels:

• National Institutes of Health Study Section – Scientific Review Group Member,
  dates of review meeting: April 10 to April 11, 2005; NIDDK
  Special Emphasis Panel: Digestive Diseases Research Core Centers (P30)
  (ZDK1 GRB-8 M1; Silvio O. Conte Digestive Diseases Research Core Centers)
• Swiss National Science Foundation scientific reviewer January 2006.
• National Institutes of Health Study Section – Scientific Review Group Member (temporary), Dates of review meeting: March 17, 2006
• NIDDK Special Emphasis Panel: Digestive Diseases K-Series Career Development Awards, ZDK1 GRB-G (M2)
• National Institutes of Health Study Section – Scientific Review Group Member (temporary), Dates of review meeting: November 30, 2006, NIDDK Special Emphasis Panel: Small Clinical Grants in Biliary Disorders Program Announcement PAR06-171; R03 Grant Mechanism, ZDK1 GRB-8 J3 1
• Iowa Board of Medical Examiners Peer Review Committee June 2006 to June 2011. Medical Expert in Bariatric Surgery and Gastrointestinal Surgery
• Research Committee, American Society for Metabolic and Bariatric Surgery 2009-