Radiology Faculty

Eric A. Hoffman, PhD

Professor Division: Physiologic Imaging Office Address: C748 GH Phone: (319) 353-6199 Fax: (319) 356-2220 eric-hoffman@uiowa.edu Curriculum Vitae Website: http://www.i-clic.uihc.uiowa.edu/

EDUCATION

Undergraduate: Graduate: Fellowships:

BA, Physiologic Psychology, Antioch College, Yellow Springs, OH, 1974 Psychology, University of Southhampton, England, 1971-72 PhD, Physiology, University of Minnesota / Mayo Graduate School of Medicine, Rochester, MN, 1981 Biodynamics Research Unit, Department of Physiology and Biophysics, Mayo Foundation, Rochester, MN, 1975-1984

RESEARCH INTERESTS

1. Dynamic, volumetric physiologic imaging and image analysis with specific emphasis on the cardiopulmonary system
2. Cardiopulmonary physiology: cardiac and pulmonary mechanics; pulmonary ventilation and perfusion; medical informatics; outcomes predictors and measures in multi-center trials; image data transmission, archiving, and quality control

Current Projects
1. Pulmonary ventilation/perfusion relationships: the evaluation of the non-gravitational determinants of pulmonary ventilation and perfusion matching; altered relationships in pathologic states such as early lung inflammation or acute pulmonary embolism
2. Airway reactivity via HRCCT: utilizing volumetric high resolution cine CT scanning to evaluate intrapulmonary airway reactivity. Particular interest for use in the etiology and treatment of asthma.
3. Objective Quantitative Imaging-based evaluation of lung parenchymal pathology
4. Development of a Standardized Lung Atlas representing the range of normality of regional pulmonary structural and functional parameters measured via high speed, multi-slice, spiral CT. The atlas will then be used to compare individuals with suspected pulmonary abnormalities and to follow early progression/regression of disease.
5. Cardiac Mechanics: evaluation of the mechanism for the integrated functioning of the heart whereby the total heart volume (contents of the pericardial sac) remains essentially constant throughout the cardiac cycle. Coupled with this, we are evaluating the interaction between the heart and lungs with both positive and negative pressure respiration. Positive pressure breathing, timed to occur in systole improves cardiac output by as much as 30%
6. Evaluation of cardiac mechanical efficiency following congenital heart repair

AREAS AVAILABLE FOR CONSULTATION

Volumetric and functional imaging
Image display and analysis

LINKS OF INTEREST

Video of Dr. Hoffman presented at the 2007 IEEE/ACM Annual Meeting