Unexposed non-tobacco user Passive exposure Nicotine Less than 2 ng/mL Less than 20 ng/mL Cotinine Less than 5 ng/mL Less than 20 ng/mL 3-OH-Cotinine Less than 50 ng/mL Less than 50 ng/mL Nornicotine Less than 2 ng/mL Less than 2 ng/mL Anabasine Less than 3 ng/mL Less than 3 ng/mL Abstinent user for greater Active tobacco product use than 2 weeks Nicotine Less than 30 ng/mL 1000 - 5000 ng/mL Cotinine Less than 50 ng/mL 1000 - 8000 ng/mL 3-OH-Cotinine Less than 120 ng/mL 3000 - 25000 ng/mL Nornicotine Less than 2 ng/mL 30 - 900 ng/mL Anabasine Less than 3 ng/mL 3 - 500 ng/mL* Reference: Clinical Chemistry 2002;48:1460-1471

Compounds covered: nicotine, cotinine, 3-OH-cotinine, nornicotine, and anabasine. Positive cutoff for anabasine is 3 ng/mL; 2 ng/mL for all other compounds. The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. For medical purposes only; not valid for forensic use.