Specimen:

Peripheral Blood

Minimum:

5-10 cc adult, 2 cc infants of venous blood collected in a green-top 
vacutainer with sodium heparin.  Invert tube to mix well.  Label the 
tube with patient name and medical record number.  DO NOT FREEZE OR 
CENTRIFUGE.

Delivery Instructions:

Submit specimen to laboratory as soon as possible after collection.

Specimen
Instructions:

Provide details of clinical information.  If a specimen is collected 
over the weekend, please page the technologist on call by dialing 
1-888-533-0186.  When it stops ringing, enter your phone number, the 
'#' sign, and hang up.

Testing Schedule:

Specimens accepted in the lab Monday-Friday, 0800-1700.  After hours 
specimens should be taken to specimen control and a message left on the 
lab voice mail.  In the case of an emergency, follow the instructions 
on the lab voice mail.

Analytic Time:

Allow 3-5 days for final results.

Reference Range:

Varies for each probe (set).  Unique sequence probes labeled with 
fluorochrome.  Contact lab for details.

Comments:

This test can be used as an adjunct to chromosomal analysis for 
detection of residual disease.  Suitable for interphase and metaphase 
analysis.

Probes currently available include: ALK [2p23], AML1/ETO [t(8;21)], 
BCR/ABL [t(9;22)], CBFB [inv (16)], Cep7/D7S522[-7 and del(7q31)], Cep8 
[trisomy 8], Cep12 [trisomy 12], CepX/Y[transplants], CLL probe panel, 
D13S319[del(13q)], D13S25[del(13q)], EGR1[del(5q31)], 
IgH/BCL-2[t(14;18)], IgH/CCND1[t(11;14)], IgH/MYC[t(8;14)], MLL 
[del(11)(q23)], N-MYC [2p24.1 or for amplification 2p24.1], p53 
[del(17)(p13.1)], PML/RARA [t(15;17)], Rb1 [del(13)(q14)], TEL/AML1 
[t(12;21)].  If the desired FISH probe is not listed, call the 
laboratory.

*CEP = centromere enumeration probe


Cytogenetics Laboratory Web Site

Methodology:

Fluorescence In-Situ Hybridization (FISH)

CPT Code:

88237, 88271, 88275, 88365

See Additional Information:
Cytogenetics Testing