Welcome to the Tan laboratory in the departments of internal medicine and biomedical engineering at the University of Iowa.

Research

Our lab is interested in Systems Biology of gene regulation. Within this broadly-defined research area, we focus most of our effort on understanding gene regulatory networks and molecular pathways that give rise to stem cell phenotype and human diseases. These efforts will help us better understand how the different processes controlling gene expression are coordinated in the cell and deepen our knowledge of organismal development and disease processes. Towards this goal, we are conducting both computational and experimental research.

[More about our current research interests...]

Recent Publications

[1] Tan K*, Feizi H, Luo C, Fan S, Ravasi T, and Ideker T.  2008. A systems approach to delineate functions of paralogous transcription factors: Role of the Yap family in the DNA damage response. Proc. Natl. Acad. Sci. 105(8):2934-2939. (Corresponding author, Highlighted by Faculty of 1000). [pubmed link]

[2] Tan K*, Tegner J, and Ravasi T.  2008.  Integrated approaches to uncover transcriptional regulatory networks in mammalian cells.  Genomics. 91(3): 219-231. (Corresponding author). [pubmed link]

[3] Tan K, Shlomi T, Feizi, H, Ideker T, and Sharan R. Transcriptional regulation of protein complexes within and across species. 2007. Proc. Natl. Acad. Sci. 104(4): 1283-1288. [pubmed link]

[4] Tan K and Ideker T.  2007. Protein interaction networks. in Biological networks. World Scientific, New Jersey.

[More about our publications...]