microRNAs in Cell Differentiation


Our research into gene transfer and RNAi for central nervous diseases have lead to studies investigating the roles microRNAs (miRNAs) play in neurogenesis and brain development.  It is known that miR

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.
Neurobiol Dis. 2013 Jan 30. (Abstract)

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.
Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL.
Nucleic Acids Res. 2013 Jan 7;41(1) (Abstract)

In vivo SELEX for Identification of Brain-penetrating Aptamers.
Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.
Mol Ther Nucleic Acids. 2013 Jan 8. (Abstract)

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.
Neurobiol Dis. 2013 Jan 30. (Abstract)

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.
Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL.
Nucleic Acids Res. 2013 Jan 7;41(1) (Abstract)

In vivo SELEX for Identification of Brain-penetrating Aptamers.
Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.
Mol Ther Nucleic Acids. 2013 Jan 8. (Abstract)

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.
Neurobiol Dis. 2013 Jan 30. (Abstract)

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.
Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL.
Nucleic Acids Res. 2013 Jan 7;41(1) (Abstract)

In vivo SELEX for Identification of Brain-penetrating Aptamers.
Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.
Mol Ther Nucleic Acids. 2013 Jan 8. (Abstract)

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.
Neurobiol Dis. 2013 Jan 30. (Abstract)

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.
Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL.
Nucleic Acids Res. 2013 Jan 7;41(1) (Abstract)

In vivo SELEX for Identification of Brain-penetrating Aptamers.
Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.
Mol Ther Nucleic Acids. 2013 Jan 8. (Abstract)

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.
Neurobiol Dis. 2013 Jan 30. (Abstract)

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.
Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL.
Nucleic Acids Res. 2013 Jan 7;41(1) (Abstract)

In vivo SELEX for Identification of Brain-penetrating Aptamers.
Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.
Mol Ther Nucleic Acids. 2013 Jan 8. (Abstract)

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.
Neurobiol Dis. 2013 Jan 30. (Abstract)

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.
Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL.
Nucleic Acids Res. 2013 Jan 7;41(1) (Abstract)

In vivo SELEX for Identification of Brain-penetrating Aptamers.
Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.
Mol Ther Nucleic Acids. 2013 Jan 8. (Abstract)

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.
Neurobiol Dis. 2013 Jan 30. (Abstract)

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.
Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL.
Nucleic Acids Res. 2013 Jan 7;41(1) (Abstract)

In vivo SELEX for Identification of Brain-penetrating Aptamers.
Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.
Mol Ther Nucleic Acids. 2013 Jan 8. (Abstract)

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.
Neurobiol Dis. 2013 Jan 30. (Abstract)

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.
Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL.
Nucleic Acids Res. 2013 Jan 7;41(1) (Abstract)

In vivo SELEX for Identification of Brain-penetrating Aptamers.
Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.
Mol Ther Nucleic Acids. 2013 Jan 8. (Abstract)

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.
Neurobiol Dis. 2013 Jan 30. (Abstract)

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.
Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL.
Nucleic Acids Res. 2013 Jan 7;41(1) (Abstract)

In vivo SELEX for Identification of Brain-penetrating Aptamers.
Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.
Mol Ther Nucleic Acids. 2013 Jan 8. (Abstract)

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.
Neurobiol Dis. 2013 Jan 30. (Abstract)

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.
Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL.
Nucleic Acids Res. 2013 Jan 7;41(1) (Abstract)

In vivo SELEX for Identification of Brain-penetrating Aptamers.
Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.
Mol Ther Nucleic Acids. 2013 Jan 8. (Abstract)

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.
Neurobiol Dis. 2013 Jan 30. (Abstract)

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.
Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL.
Nucleic Acids Res. 2013 Jan 7;41(1) (Abstract)

In vivo SELEX for Identification of Brain-penetrating Aptamers.
Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.
Mol Ther Nucleic Acids. 2013 Jan 8. (Abstract)

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.
Neurobiol Dis. 2013 Jan 30. (Abstract)

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.
Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL.
Nucleic Acids Res. 2013 Jan 7;41(1) (Abstract)

In vivo SELEX for Identification of Brain-penetrating Aptamers.
Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.
Mol Ther Nucleic Acids. 2013 Jan 8. (Abstract)

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.
Neurobiol Dis. 2013 Jan 30. (Abstract)

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.
Boudreau RL, Spengler RM, Hylock RH, Kuse

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.
Neurobiol Dis. 2013 Jan 30. (Abstract)

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.
Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL.
Nucleic Acids Res. 2013 Jan 7;41(1) (Abstract)

In vivo SELEX for Identification of Brain-penetrating Aptamers.
Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.
Mol Ther Nucleic Acids. 2013 Jan 8. (Abstract)

nda BJ, Davis HA, Eichmann DA, Davidson BL.
Nucleic Acids Res. 2013 Jan 7;41(1) (Abstract)

In vivo SELEX for Identification of Brain-penetrating Aptamers.
Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.
Mol Ther Nucleic Acids. 2013 Jan 8. (Abstract)

NAs are required for embryonic viability and proper brain developement.  We are investigating the roles specific miRNAs have in brain stem cell differentiation(1-4). 



microRNAs in Disease

Additionally, we are looking at the differential profiles of microRNA expression and targets in genetic disease and the roles miRNAs have in disease, specifically, Huntington's Disease (5). 


References:

1. Dicer is required for proliferation, viability, migration and differentiation in corticoneurogenesis. McLoughlin HS, Fineberg SK, Ghosh LL, Tecedor L, Davidson BL. Neuroscience. 2012 Oct 25;223:285-95. (Abstract)

2. MiR-34a represses Numbl in murine neural progenitor cells and antagonizes neuronal differentiation. Fineberg SK, Datta P, Stein CS, Davidson BL. PLoS One. 2012;7(6). (Abstract)

3. Adenosine deamination in human transcripts generates novel microRNA binding sites. Borchert GM, Gilmore BL, Spengler RM, Xing Y, Lanier W, Bhattacharya D, Davidson BL Hum Mol Genet. 2009 Dec 15;18(24):4801-7. (Abstract)

4. MicroRNAs potentiate neural development. Fineberg SK, Kosik KS, Davidson BL. Neuron. 2009 Nov 12;64(3):303-9. (Abstract)

5. The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease.  Packer AN, Xing Y, Harper SQ, Jones L, Davidson BL. J Neurosci. 2008 Dec 31;28(53):14341-6. (Abstract)







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