University of Iowa Carver College of Medicine

Carver Biomedical Research Building

2256 CBRB
Iowa City, IA 52242

Phone: 319-335-8954
mei-ling-joiner@uiowa.edu

 

Mei-Ling Joiner, Ph.D.
Assistant Research Professor

Cellular communication, particularly interaction among excitable cells, is an area of intense study. Molecules involved in the interaction between such excitable cells as neurons or cardiomyocytes are targets for drug development aimed at improving lives of people afflicted with neurological and cardiovascular diseases. Multifunctional CaMKII, an enzyme central to processes leading to cell excitability, regulates ion channel activity and metabolism. Mitochondria are vital to energy metabolism and utilize ion channels to interact with other cellular components. One approach to understand its effect on mitochondrial processes is to vary levels of CaMKII. My research interest in how excitable cells function is applied at many levels, using methods ranging from MALDI-TOF, to protein identification at the molecular level, to cellular models, to using transgenic animals at the whole organism level.

Recent Publications

  1. Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, HeBJ, Luczak ED, Joiner ML, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, Ogawa M, Chen PS, Efimov I, Dobrev D, Mohler PJ, Hund TJ, Anderson ME. Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J Clin Invest. 2011 Aug;121(8):3277-88. doi: 10.1172/JCI57833. Epub 2011 Jul 25. PubMed PMID:
    21785215; PubMed Central PMCID: PMC3223923.
  2. He BJ, Joiner ML, Singh MV, Luczak ED, Swaminathan PD, Koval OM, Kutschke W, Allamargot C, Yang J, Guan X, Zimmerman K, Grumbach IM, Weiss RM, Spitz DR,
    Sigmund CD, Blankesteijn WM, Heymans S, Mohler PJ, Anderson ME. Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med. 2011 Nov
    13;17(12):1610-8. doi: 10.1038/nm.2506. PubMed PMID: 22081025; PubMed Central PMCID: PMC3332099.
  3. Joiner ML, Koval OM, Li J, He BJ, Allamargot C, Gao Z, Luczak ED, Hall DD, Fink BD, Chen B, Yang J, Moore SA, Scholz TD, Strack S, Mohler PJ, Sivitz WI, Song LS, Anderson ME. CaMKII determines mitochondrial stress responses in heart.
    Nature. 2012 Nov 8;491(7423):269-73. doi: 10.1038/nature11444. Epub 2012 Oct 10.
    PubMed PMID: 23051746; PubMed Central PMCID: PMC3471377.
  4. Gao Z, Rasmussen TP, Li Y, Kutschke W, Koval OM, Wu Y, Wu Y, Hall DD, Joiner
    ML, Wu X, Dominic Swaminathan P, Purohit A, Zimmerman KA, Weiss RM, Philipson K,
    Song LS, Hund TJ, Anderson ME. Genetic Inhibition of Na+-Ca2+ Exchanger Current
    Disables Fight or Flight Sinoatrial Node Activity Without Affecting Resting Heart
    Rate. Circ Res. 2012 Nov 27. [Epub ahead of print] PubMed PMID: 23192947.

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