Sossalla S, Maurer U, Schotola H, Hartmann N, Didié M, Zimmermann WH,
Jacobshagen C, Wagner S, Maier LS. Diastolic dysfunction and arrhythmias caused
by overexpression of CaMKIIδ(C) can be reversed by inhibition of late Na (+)
current. Basic Res Cardiol. 2010 Dec 21. [Epub ahead of print] PubMed PMID:
21174213.

van Oort RJ, McCauley MD, Dixit SS, Pereira L, Yang Y, Respress JL, Wang Q, De
Almeida AC, Skapura DG, Anderson ME, Bers DM, Wehrens XH. Ryanodine receptor
phosphorylation by calcium/calmodulin-dependent protein kinase II promotes
life-threatening ventricular arrhythmias in mice with heart failure. Circulation.
2010 Dec 21;122(25):2669-79. Epub 2010 Nov 15. PubMed PMID: 21098440.

Bers DM. CaMKII inhibition in heart failure makes jump to human. Circ Res.
2010 Oct 29;107(9):1044-6. Review. PubMed PMID: 21030721.

Huke S, Desantiago J, Kaetzel MA, Mishra S, Brown JH, Dedman JR, Bers DM.
SR-targeted CaMKII inhibition improves SR Ca(2+) handling, but accelerates
cardiac remodeling in mice overexpressing CaMKIIδ(C). J Mol Cell Cardiol. 2010
Oct 21. [Epub ahead of print] PubMed PMID: 20971119.

Liu N, Ruan Y, Denegri M, Bachetti T, Li Y, Colombi B, Napolitano C, Coetzee
WA, Priori SG. Calmodulin kinase II inhibition prevents arrhythmias in
RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia.
J Mol Cell Cardiol. 2010 Oct 23. [Epub ahead of print] PubMed PMID: 20937285.

Wehrens XH. CaMKII regulation of the cardiac ryanodine receptor and
sarcoplasmic reticulum calcium release. Heart Rhythm. 2010 Sep 29. [Epub ahead of
print] PubMed PMID: 20887810.

Maier LS. CaMKII regulation of voltage-gated sodium channels and cell
excitability. Heart Rhythm. 2010 Sep 29. [Epub ahead of print] PubMed PMID:
20887805.

Hund TJ, Koval OM, Li J, Wright PJ, Qian L, Snyder JS, Gudmundsson H, Kline
CF, Davidson NP, Cardona N, Rasband MN, Anderson ME, Mohler PJ. A
β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in
mice. J Clin Invest. 2010 Oct 1;120(10):3508-19. doi: 10.1172/JCI43621. Epub 2010
Sep 27. PubMed PMID: 20877009; PubMed Central PMCID: PMC2947241.

Sossalla S, Fluschnik N, Schotola H, Ort KR, Neef S, Schulte T, Wittköpper K,
Renner A, Schmitto JD, Gummert J, El-Armouche A, Hasenfuss G, Maier LS.
Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves
contractility in human failing myocardium. Circ Res. 2010 Oct 29;107(9):1150-61.
Epub 2010 Sep 2. PubMed PMID: 20814023.

Seidler T, Teucher N, Hellenkamp K, Unsöld B, Grebe C, Kramps P, Schotola H,
Wagner S, Schöndube FA, Hasenfuss G, Maier LS. Limitations of FKBP12.6-directed
treatment strategies for maladaptive cardiac remodeling and heart failure. J Mol
Cell Cardiol. 2010 Aug 24. [Epub ahead of print] PubMed PMID: 20797399.

Toischer K, Rokita AG, Unsöld B, Zhu W, Kararigas G, Sossalla S, Reuter SP,
Becker A, Teucher N, Seidler T, Grebe C, Preuss L, Gupta SN, Schmidt K, Lehnart
SE, Krüger M, Linke WA, Backs J, Regitz-Zagrosek V, Schäfer K, Field LJ, Maier
LS, Hasenfuss G. Differential cardiac remodeling in preload versus afterload.
Circulation. 2010 Sep 7;122(10):993-1003. Epub 2010 Aug 23. PubMed PMID:
20733099; PubMed Central PMCID: PMC2955196.

Dobrev D, Wehrens XH. Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak,
and atrial fibrillation. Trends Cardiovasc Med. 2010 Jan;20(1):30-4. Review.
PubMed PMID: 20685575; PubMed Central PMCID: PMC2917388.

Aye TT, Scholten A, Taouatas N, Varro A, Van Veen TA, Vos MA, Heck AJ.
Proteome-wide protein concentrations in the human heart. Mol Biosyst. 2010 Oct
1;6(10):1917-27. Epub 2010 Jul 1. PubMed PMID: 20596566.

Mishra S, Ling H, Grimm M, Zhang T, Bers DM, Brown JH. Cardiac Hypertrophy
and Heart Failure Development Through Gq and CaM Kinase II Signaling. J
Cardiovasc Pharmacol. 2010 Jun 7. [Epub ahead of print] PubMed PMID: 20531218;
PubMed Central PMCID: PMC2947575.

Curran J, Brown KH, Santiago DJ, Pogwizd S, Bers DM, Shannon TR. Spontaneous
Ca waves in ventricular myocytes from failing hearts depend on
Ca(2+)-calmodulin-dependent protein kinase II. J Mol Cell Cardiol. 2010
Jul;49(1):25-32. Epub 2010 Mar 29. PubMed PMID: 20353795; PubMed Central PMCID:
PMC2883657.

Bers DM. Calcium channels are ganging up in the sarcolemma. Circ Res. 2010
Mar 5;106(4):625-6. PubMed PMID: 20203310; PubMed Central PMCID: PMC2839079.

Koval OM, Guan X, Wu Y, Joiner ML, Gao Z, Chen B, Grumbach IM, Luczak ED,
Colbran RJ, Song LS, Hund TJ, Mohler PJ, Anderson ME. CaV1.2 beta-subunit
coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations. Proc
Natl Acad Sci U S A. 2010 Mar 16;107(11):4996-5000. Epub 2010 Mar 1. PubMed PMID:
20194790; PubMed Central PMCID: PMC2841943.

Sipido KR, Vangheluwe P. Targeting sarcoplasmic reticulum Ca2+ uptake to
improve heart failure: hit or miss. Circ Res. 2010 Feb 5;106(2):230-3. PubMed
PMID: 20133907.

Schott P, Jacobshagen C, Köhler J, Seidler T, Asif AR, Dihazi H, Hasenfuss G,
Maier LS. Proteome changes in CaMKIIδC-overexpressing cardiac myocytes.
Cardiovasc Pathol. 2010 Nov-Dec;19(6):e241-50. Epub 2010 Jan 25. PubMed PMID:
20093047.

Neef S, Dybkova N, Sossalla S, Ort KR, Fluschnik N, Neumann K, Seipelt R,
Schöndube FA, Hasenfuss G, Maier LS. CaMKII-dependent diastolic SR Ca2+ leak and
elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial
fibrillation. Circ Res. 2010 Apr 2;106(6):1134-44. Epub 2010 Jan 7. PubMed PMID:
20056922.

Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers DM, Brown
JH. Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but
exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res. 2010
Feb 5;106(2):354-62. Epub 2009 Dec 3. PubMed PMID: 19959778; PubMed Central
PMCID: PMC2818826.

Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009 Jul;119(7):1940-51. PubMed PMID: 19603549; PubMed Central PMCID: PMC2701862.

Han F, Tucker AL, Lingrel JB, Despa S, Bers DM. Extracellular Potassium Dependence of the Na+/K+-ATPase in Cardiac Myocytes; Isoform Specificity and Effect of Phospholemman. Am J Physiol Cell Physiol. 2009 Jul 1. [Epub ahead of print] PubMed PMID: 19570895.

Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5972-7. Epub 2009 Mar 10. PubMed PMID: 19276108; PubMed Central PMCID: PMC2667018.

Ruan Y, Liu N, Priori SG. Sodium channel mutations and arrhythmias. Nat Rev Cardiol. 2009 May;6(5):337-48. Review. PubMed PMID: 19377496.

Anderson ME. CaMKII and a failing strategy for growth in heart. J Clin Invest. 2009 May;119(5):1082-5. PubMed PMID: 19422097; PubMed Central PMCID: PMC2673844.

Dadvar P, O'Flaherty M, Scholten A, Rumpel K, Heck AJ. A chemical proteomics based enrichment technique targeting the interactome of the PDE5 inhibitor PF-4540124. Mol Biosyst. 2009 May;5(5):472-82. Epub 2009 Mar 13. PubMed PMID: 19381362.

Andrienko TN, Picht E, Bers DM. Mitochondrial free calcium regulation during sarcoplasmic reticulum calcium release in rat cardiac myocytes. J Mol Cell Cardiol. 2009 Jun;46(6):1027-36. Epub 2009 Apr 1. PubMed PMID: 19345225; PubMed Central PMCID: PMC2683203.

Singh MV, Kapoun A, Higgins L, Kutschke W, Thurman JM, Zhang R, Singh M, Yang J, Guan X, Lowe JS, Weiss RM, Zimmermann K, Yull FE, Blackwell TS, Mohler PJ, Anderson ME. Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. J Clin Invest. 2009 Apr;119(4):986-96. doi: 10.1172/JCI35814. Epub 2009 Mar 9. PubMed PMID: 19273909; PubMed Central PMCID: PMC2662543.

Ideker RE, Kong W, Pogwizd S. Purkinje fibers and arrhythmias. Pacing Clin Electrophysiol. 2009 Mar;32(3):283-5. PubMed PMID: 19272054. Backs J, Backs T, Neef S, Kreusser MM, Lehmann LH, Patrick DM, Grueter CE, Qi X, Richardson JA, Hill JA, Katus HA, Bassel-Duby R, Maier LS, Olson EN. The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2342-7. Epub 2009 Jan 28. PubMed PMID: 19179290; PubMed Central PMCID: PMC2650158.

Decker KF, Heijman J, Silva JR, Hund TJ, Rudy Y. Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium. Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H1017-26. Epub 2009 Jan 23. PubMed PMID: 19168720; PubMed Central PMCID: PMC2670702.

Anderson ME, Mohler PJ. Rescuing a failing heart: think globally, treat locally. Nat Med. 2009 Jan;15(1):25-6. PubMed PMID: 19129780.

Aye TT, Mohammed S, van den Toorn HW, van Veen TA, van der Heyden MA, Scholten A, Heck AJ. Selectivity in enrichment of cAMP-dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins. Mol Cell Proteomics. 2009 May;8(5):1016-28. Epub 2008 Dec 31. PubMed PMID: 19119138; PubMed Central PMCID: PMC2689760.

Vincent GM, Schwartz PJ, Denjoy I, Swan H, Bithell C, Spazzolini C, Crotti L, Piippo K, Lupoglazoff JM, Villain E, Priori SG, Napolitano C, Zhang L. High efficacy of beta-blockers in long-QT syndrome type 1: contribution of noncompliance and QT-prolonging drugs to the occurrence of beta-blocker treatment"failures". Circulation. 2009 Jan 20;119(2):215-21. Epub 2008 Dec 31. PubMed PMID: 19118258.

Donahue JK. Novel strategy to reduce sudden-death risk in the healing phase after myocardial infarction. Circulation. 2009 Jan 6;119(1):6-8. Epub 2008 Dec 22. PubMed PMID: 19103983.

Fernández-Velasco M, Rueda A, Rizzi N, Benitah JP, Colombi B, Napolitano C, Priori SG, Richard S, Gómez AM. Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia. Circ Res. 2009 Jan 30;104(2):201-9, 12p following 209. Epub 2008 Dec 18. PubMed PMID: 19096022.

Hund TJ, Wright PJ, Dun W, Snyder JS, Boyden PA, Mohler PJ. Regulation of the ankyrin-B-based targeting pathway following myocardial infarction. Cardiovasc Res. 2009 Mar 1;81(4):742-9. Epub 2008 Dec 14. PubMed PMID: 19074823; PubMed Central PMCID: PMC2642599.

Johnson JN, Hofman N, Haglund CM, Cascino GD, Wilde AA, Ackerman MJ. Identification of a possible pathogenic link between congenital long QT syndrome and epilepsy. Neurology. 2009 Jan 20;72(3):224-31. Epub 2008 Nov 26. PubMed PMID: 19038855; PubMed Central PMCID: PMC2677528.

Sasano T, Kelemen K, Greener ID, Donahue JK. Ventricular tachycardia from the healed myocardial infarction scar: validation of an animal model and utility of gene therapy. Heart Rhythm. 2009 Aug;6(8 Suppl):S91-7. Epub 2009 Apr 1. PubMed PMID: 19631912.

Silva JR, Pan H, Wu D, Nekouzadeh A, Decker KF, Cui J, Baker NA, Sept D, Rudy Y. A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential. Proc Natl Acad Sci U S A. 2009 July. 7;106(27):11102-6. Epub 2009 Jun 22. PubMed PMID: 19549851; PubMed Central PMCID: PMC2700153.

Backs J, Backs T, Neef S, Kreusser MM, Lehmann LH, Patrick DM, Grueter CE, Qi X, Richardson JA, Hill JA, Katus HA, Bassel-Duby R, Maier LS, Olson EN. The delta isoform of CaM Kinase II is required for pathological cardiac hypertrophy and modeling after pressure overload. Proc Natl Acad Sci U S A. 106;2342-2347.2009

Wagner S, Hacker E, Grandi E, Weber SL, Dybkova N, Sossalla S, Sowa T, Bers DM, Maier LS. Ca/calmodulin kinase II differentially modulates potassium currents. Circ Arrhythmia Electophysiol. 2;285-294.2009

Sag Cm, Wadsack DP. Khabbazzadeh S, Abesser M, Grefe C, neef S, Maier SKG, Maier LS. CaMKII Contributes to cardiac arrhythmogenesis in transgenic CaMKIIdeltaC mice having heart failure. Circ Heart Fail. 2:664-75.2009.

(Selected publications out of > 50. Follow link for complete list on Pubmed.)

Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Barlett RK, Lowe JS, O'Donnell SE, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AJ, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME. A dynamic pathway for calcium-independent activation of CaMKII by methione oxidation. Cell. 2008 May 2;133(3):462-74.

Huke S, Bers DM. Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. Biochem Biophys Res Commun. 2008 Aug 25.

Bierhuizen MF, Boulaksil M, van Stuijvenberg L, van der Nagel R, Jansen AT, Mutsaers NA, Yildrim C, van Veen TA, de Windt LJ, Vos MA, van Rijen HV. In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms. J Mol Cell Cardiol. 2008 Jul 11.

Hund TJ, Decker KF, Kanter E, Mohler PJ, Boyden PA, Schuessler RB, Yamada KA, Rudy Y. Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: Insights from mathematical modeling. J Mol Cell Cardiol. 2008.

Desantiago J, Ai X, Islam M, Acuna G, Ziolo MT, Bers DM, Pogwizd SM. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 6;102(11):1389-97.

Ozdemir S, Bito V, Holemans P, Vinet L, Mercadier J, Varro A, Sipido KR. Pharmacological inhibition of Na/Ca exchange results in increased cellular Ca2+ load attributable to the predominance of forward mode block. Circ Res. 2008 Jun 6;102(11):1398-405.

Werdich AA, Lima EA, Dzhura I, Singh MV, Li J, Anderson ME, Baudenbacher FJ. Differential effects of phospholamban and Ca2+/calmodulin-dependent kinase II on [Ca2+]i-transients in cardiac myocytes at physiological stimulation frequencies. Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2352-62.

Chen PS and Priori SG. The Brugada syndrome. J Am Coll Cardiol. 2008;51:1176-80.

Mohler PJ and Anderson ME. New insights into genetic causes of sinus node dysfunction and atrial fibrillation. J Cardiovasc Electrophys. 2008 May;19(5):516-8.

Scholten A, Aye TT, Heck AJ. A multi-angular mass spectrometric view at cyclic nucleotide dependent protein kinases: In vivo characterization and structure/function relationships. Mass Spectrom Rev. 2008 Jul-Aug;27(4):331-53.

Kelly EM, Hou Z, Bossuyt J, Bers DM, Robia SL. Phospholamban oligomerization, quaternary structure, and SERCA-binding measured by FRET in living cells. J Biol Chem. 2008.

Boveri L, Priori SG. Molecular strategies for the electrophysiologist. Nat Clin Pract Cardiovasc Med. 2008 Mar;5(3):117.

Kline CF, Cunha SR, Lowe JS, Hund TJ, Mohler PJ. Revisiting ankyrin-InsP(3) receptor interactions: Ankyrin-B associates with the cytoplasmic N-terminus of the InsP(3) receptor. J Cell Biochem. 2008.

Bossuyt J, Helmstadter K, Wu X, Clements-Jewery H, Haworth RS, Avkiran M, Martin J, Pogwizd SM, Bers DM. Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Circ Res. 2008 Mar;102(6):695-702.

El Yaman M, Perry J, Makielski JC, Ackerman MJ. Suppression of atrial fibrillation with mexiletine pharmacotherapy in a young woman with type 1 long QT syndrome. Heart Rhythm. 2008 Mar;5(3):472-4.

Jansen JA, de Boer TP, Wolswinkel R, van Veen TA, Vos MA ,van Rijen HV, van der Heyden MA. Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density. Biochem Biophys Fes Commun. 2008 Mar 14;367(3):687-92.

Lowe JS, Palygin O, Bhasin N, Hund TJ, Boyden PA, Shibata E, Anderson ME, Mohler PJ. Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway. J Cell Biol. 2008 Jan 14;180(1):173-86.

Hinterseer M, Thomsen MB, Beckmann BM, Pfeufer A, Schimpf R, Wichmann HE, Steinbeck G, Vos MA, Kaab S. Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study. Eur Heart J. 2008 Jan;29(2):185-90.

Kockskamper J, Seidlmayer L, Walther S, Hellenkamp K, Maier LS, Pieske B. Endothelin-1 enhances nuclear Ca2+ transients in atrial myocytes through Ins(1,4,5)P3-dependent Ca2+ release from perinuclear Ca2+ stores. J Cell Sci. 2008 Jan 15;121:186-95.

Khoo MS, Grueter CE, Eren M, Yang J, Zhang R, Bass MA, Lwin ST, Mendes LA, Vaughan DE, Colbran RJ, Anderson ME. Calmodulin kinase II inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein. J Mol Cell Cardiol. 2008 Feb;44(2):405-10.

(Selected publications out of > 150. Follow link for complete list on Pubmed.)

Zhang T, Kohlhaas M, Backs J, Mishra S, Phillips W. Dybkova N, Chang S, Ling H. Bers DM, Maier LS, Olson EN, Brown JH. CaMKII delta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. J Biol Chem. 2007 Nov 30;282(48):35078-87.

Guo T, Ai X, Shannon TR, Pogwizd SM, Bers DM. Intra-sarcoplasmic reticulum free [Ca2+] and buffering in arrhythmogenic failing rabbit heart. Circ Res. 2007;101:802-10.

Grandi E, Puglisi JL, Wagner S, Maier LS, Severi S, Bers DM. Simulation of Ca/Calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J. 2007 Dec 1;93(11):3835-47.

Maier LS, Bers DM, Brown JH.
Calmodulin and Ca2+/calmodulin kinases in the heart - physiology and pathophysiology.
Cardiovasc Res. 2007 Mar;73:629-30.

Maier LS, Bers DM. Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res. 2007 Mar;73:631-40.

Lehnart SE, Ackerman MJ, Benson DW Jr, Brugada R, Clancy CE, Donahue JK, George AL Jr, Grant AO, Groft SC, January CT, Lathrop DA, Lederer WJ, Makielski JC, Mohler PJ, Moss A, Nerbonne JM, Olson TM, Przywara DA, Towbin JA, Wang LH, Marks AR. Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function. Circulation. 2007 Nov 13;116(20):2325-45.

Landstrom AP, Weisleder N, Batalden KB, Bos JM, Tester DJ, Ommen SR, Wehrens XH, Claycomb WC, Ko JK, Hwang M, Pan Z, Ma J, Ackerman MJ. Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. J Mol Cell Cardiol. 2007 Jun;42(6):1026-35.

Seth R, Moss AJ, McNitt S, Zareba W, Andrews ML, Qi M, Robinson JL, Goldenberg I, Ackerman MJ, Benhorin J, Kaufman ES, Locati EH, Napolitano C, Priori SG, Schwartz PJ, Towbin JA, Vincent GM, Zhang L. Long QT syndrome and pregnancy. J Am Coll Cardiol. 2007 Mar 13;49(10):1092-8.

Mohler PJ and Wehrens XH. Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions. Physiology (Bethesda). 2007 Oct;22:342-50.

Anderson ME, Mohler PJ. MicroRNA may have macro effect on sudden death. Nat Med. 2007 Apr;13:410-1.

Anderson ME. Multiple downstream proarrhythmic targets for calmodulin kinase II: moving beyond an ion channel-centric focus. Cardiovasc Res. 2007; 16;122:185-9.

Ruan Y, Liu N, Bloise R, Napolitano C, Priori SG. Gating properties of SCN5A mutations and the response to mexiletine in long-QT syndrome type 3 patients. Circulation 2007 Sep;116:1137-44.

Napolitano C, Priori SG. Diagnosis and treatment of catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm 2007 May;4:675-8.

Sauer AJ, Moss AJ, McNitt S, Zareba W, Robinson JL, QI M, Goldenberg I, Hobbs JB, Ackerman MJ, Benhorin J, Hall WJ, Kaufman ES, Locatis EH, Napolitano C, Priori SG, Schwartz PJ, Towbin JA, Vincent GM, Zhang L. Long QT syndrome in adults. J Am Coll Cardiol. 2007 Jan;49:329-37.

Sipido KR, Bito V, Antoons G, Volders PG, Vos MA. Na/Ca exchange and cardiac ventricular arrhythmias. Ann N Y Acad Sci. 2007 Mar;1099:339-48.

Antoons G, Oros A, Bito V, Sipido KR, Vos MA.Cellular basis for triggered ventricular arrhythmias that occur in the setting of compensated hypertrophy and heart failure: considerations for diagnosis and treatment. J Electrocardiol. 2007 Nov-Dec;40(6 Suppl):S8-14.

Antoons G, Volders PG, Stankovicova T, Bito V, Stengl M, Vos MA, Sipido KR.
Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block. J Physiol. 2007 Feb 15;579(Pt 1):147-60.

Scholten A, van Veen TA, Vos MA, Heck AJ. Diversity of cAMP-dependent protein kinase isoforms and their anchoring proteins in mouse ventricular tissue. J Proteome Res. 2007 May;6(5):1705-17.

Khoo MS, Li J, Singh MV, Yang Y, Kannankeril P, Wu Y, Grueter CE, Guan X, Oddis CV, Zhang R, Mendes L, Ni G, Madu EC, Yang J, Bass M, Gomez RJ, Wadzinski BE, Olson EN, Colbran RJ, Anderson ME. Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy. Circulation 2006;114:1352-9.

Li J, Marionneau C, Zhang R, Shah V, Hell JW, Nerbonne JM, Anderson ME. Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents. Circ Res. 2006;99:1092-9.

Sasano T, McDonald AD, Kikuchi K, Donahue JK. Molecular ablation of ventricular tachycardia after myocardial infarction. Nat Med. 2006 November;12:1256-8.

Grueter CE, Abiria SA, Dzhura I, Wu Y, Ham AJ, Mohler PJ, Anderson ME, Colbran RJ. L-Type Ca2+ Channel Facilitation Mediated by Phosphorylation of the beta Subunit by CaMKII. Mol Cell. 2006 September 1;23:641-50.

Anderson ME, Higgins LS, Schulman H. Disease mechanisms and emerging therapies: protein kinases and their inhibitors in myocardial disease. Nat Clin Pract Cardiovasc Med. 2006;3:437-45.

Wu Y, Shintani A, Grueter C, Zhang R, Hou Y, Yang J, Kranias EG, Colbran RJ, Anderson ME. Suppression of dynamic Ca2+ transient responses to pacing in ventricular myocytes from mice with genetic calmodulin kinase II inhibition. J Mol Cell Cardiol. 2006 Feb;40:213-23.

Scholten A, Poh MK, van Veen TA, van BB, Vos MA, Heck AJ. Analysis of the cGMP/cAMP interactome using a chemical proteomics approach in mammalian heart tissue validates sphingosine kinase type 1-interacting protein as a genuine and highly abundant AKAP 8. J Proteome Res 2006 June;5:1435-47.

Zhang R, Khoo MS, Wu Y, Yang Y, Grueter CE, Ni G, Price EE, Thiel W, Guatimosim S, Song LS, Madu EC, Shah AN, Vishnivetskaya TA, Atkinson JB, Gurevich VV, Salama G, Lederer WJ, Colbran RJ, Anderson ME. Calmodulin kinase II inhibition protects against structural heart disease. Nat Med. 2005 Apr;11:409-17.

Anderson ME. Calmodulin kinase signaling in heart: an intriguing candidate target for therapy of myocardial dysfunction and arrhythmias. Pharmacol Ther. 2005;106:39-55.

Cerrone M, Colombi B, Santoro M, di Barletta MR, Scelsi M, Villani L, Napolitano C, Priori SG. Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor. Circ Res. 2005;96:e77-e82.

Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM. Ca2+-calmodulin-dependent protein kinase modulates RyR2 pohsphorylation and SR Ca2+ leak in heart failure. Circ Res. 2005 Dec;97:1314-22.

Bers DM. Beyond beta blockers. Nat Med. 2005 April;11:379-80.

Wehrens XH, Lehnart SE, Reiken SR, Marks AR. Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res. 2004 April 2;94:e61-e70.

Mohler PJ, Splawski I, Napolitano C, Bottelli G, Sharpe L, Timothy K, Priori SG, Keating MT, Bennett V. A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. Proc Natl Acad Sci U S A. 2004 ;101:9137-42.

Mohler PJ, Rivolta I, Napolitano C, Lemaillet G, Lambert S, Priori SG, Bennett V. Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. Proc Natl Acad Sci U S A. 2004 December 14;101(50):17533-8.

Thomsen MB, Verduyn SC, Stengl M, Beekman JD, de PG, van OJ, Volders PG, Vos MA. Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs. Circulation 2004;110:2453-9.

Hund TJ, Rudy Y. Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation 2004 November 16;110(20):3168-74.

Mohler PJ, Schott JJ, Gramolini AO, Dilly KW, Guatimosim S, duBell WH, Song LS, Haurogne K, Kyndt F, Ali ME, Rogers TB, Lederer WJ, Escande D, Le Marec H, Bennett V. Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature 2003;421:634-9.

Zhang T, Maier LS, Dalton ND, Miyamoto S, Ross J, Jr., Bers DM, Brown JH. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res. 2003;92:912-9.

Maier LS, Zhang T, Chen L, DeSantiago J, Brown JH, Bers DM. Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res. 2003;92:904-11.

Wu Y, Temple J, Zhang R, Dzhura I, Zhang W, Trimble RW, Roden DM, Passier R, Olson EN, Colbran RJ, Anderson ME. Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy. Circulation 2002 ;106:1288-93. Maier LS, Bers DM. Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond. J Mol Cell Cardiol. 2002 August;34:919-39.

Pogwizd SM, Schlotthauer K, Li L, Yuan W, Bers DM. Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ Res. 2001;88:1159-67.

Mazur A, Roden DM, Anderson ME. Systemic Administration of Calmodulin Antagonist W-7 or Protein Kinase A Inhibitor H-8 Prevents Torsade de Pointes in Rabbits. Circulation 1999;100:2437-42.