Transatlantic CaMKII Alliance

Alliance Publications

2013

Toischer K, Hartmann N, Wagner S, Fischer TH, Herting J, Danner BC, Sag CM,
Hund TJ, Mohler PJ, Belardinelli L, Hasenfuss G, Maier LS, Sossalla S. Role of
late sodium current as a potential arrhythmogenic mechanism in the progression of
pressure-induced heart disease. J Mol Cell Cardiol. 2013 Apr 6. doi:pii:
S0022-2828(13)00102-8. 10.1016/j.yjmcc.2013.03.021. [Epub ahead of print] PubMed
PMID: 23570977.

Neef S, Sag CM, Daut M, Bäumer H, Grefe C, El-Armouche A, Desantiago J,
Pereira L, Bers DM, Backs J, Maier LS. While systolic cardiomyocyte function is
preserved, diastolic myocyte function and recovery from acidosis are impaired in
CaMKIIδ-KO mice. J Mol Cell Cardiol. 2013 Jun;59:107-16. doi:
10.1016/j.yjmcc.2013.02.014. Epub 2013 Mar 6. PubMed PMID: 23473775.

Luo M, Guan X, Luczak ED, Lang D, Kutschke W, Gao Z, Yang J, Glynn P, Sossalla
S, Swaminathan PD, Weiss RM, Yang B, Rokita AG, Maier LS, Efimov IR, Hund TJ,
Anderson ME. Diabetes increases mortality after myocardial infarction by
oxidizing CaMKII. J Clin Invest. 2013 Mar 1;123(3):1262-74. doi:
10.1172/JCI65268. Epub 2013 Feb 15. PubMed PMID: 23426181.

Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J,
Bers DM. Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum
Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26;127(8):913-22. doi:
10.1161/CIRCULATIONAHA.12.148619. Epub 2013 Jan 30. PubMed PMID: 23363625.

Hamdani N, Krysiak J, Kreusser MM, Neef S, Dos Remedios CG, Maier LS, Krüger
M, Backs J, Linke WA. Crucial role for Ca2(+)/calmodulin-dependent protein
kinase-II in regulating diastolic stress of normal and failing hearts via titin
phosphorylation. Circ Res. 2013 Feb 15;112(4):664-74. doi:
10.1161/CIRCRESAHA.111.300105. Epub 2013 Jan 2. PubMed PMID: 23283722.

 2012

Ather S, Wang W, Wang Q, Li N, Anderson ME, Wehrens XH. Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy. Heart Rhythm. 2013 Apr;10(4):592-9. doi: 10.1016/j.hrthm.2012.12.016. Epub 2012 Dec 12. PubMed PMID: 23246599; PubMed Central PMCID: PMC3605194.

Sierra A, Zhu Z, Sapay N, Sharotri V, Kline CF, Luczak ED, Subbotina E, Sivaprasadarao A, Snyder PM, Mohler PJ, Anderson ME, Vivaudou M, Zingman LV, Hodgson-Zingman DM. Regulation of cardiac ATP-sensitive potassium channel surface expression by calcium/calmodulin-dependent protein kinase II. J Biol Chem. 2013 Jan 18;288(3):1568-81. doi: 10.1074/jbc.M112.429548. Epub 2012 Dec 6. PubMed PMID: 23223335; PubMed Central PMCID: PMC3548467.

Fischer TH, Neef S, Maier LS. The Ca-calmodulin dependent kinase II: A promising target for future antiarrhythmic therapies? J Mol Cell Cardiol. 2013 May;58:182-7. doi: 10.1016/j.yjmcc.2012.11.003. Epub 2012 Nov 13. PubMed PMID: 23159442.

Rokita AG, Anderson ME. New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII). Circulation. 2012 Oct 23;126(17):2125-39. doi: 10.1161/CIRCULATIONAHA.112.124990. Review. PubMed PMID: 23091085; PubMed Central PMCID: PMC3532717.

DeGrande S, Nixon D, Koval O, Curran JW, Wright P, Wang Q, Kashef F, Chiang D, Li N, Wehrens XH, Anderson ME, Hund TJ, Mohler PJ. CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm. 2012 Dec;9(12):2034-41. doi: 10.1016/j.hrthm.2012.08.026. Epub 2012 Aug 28. PubMed PMID: 23059182; PubMed Central PMCID: PMC3630478.

Joiner ML, Koval OM, Li J, He BJ, Allamargot C, Gao Z, Luczak ED, Hall DD, Fink BD, Chen B, Yang J, Moore SA, Scholz TD, Strack S, Mohler PJ, Sivitz WI, Song LS, Anderson ME. CaMKII determines mitochondrial stress responses in heart. Nature. 2012 Nov 8;491(7423):269-73. doi: 10.1038/nature11444. Epub 2012 Oct 10. PubMed PMID: 23051746; PubMed Central PMCID: PMC3471377.

He BJ, Anderson ME. Aldosterone and cardiovascular disease: the heart of the matter. Trends Endocrinol Metab. 2013 Jan;24(1):21-30. doi: 10.1016/j.tem.2012.09.004. Epub 2012 Oct 3. PubMed PMID: 23040074; PubMed Central PMCID: PMC3532553.

Koval OM, Snyder JS, Wolf RM, Pavlovicz RE, Glynn P, Curran J, Leymaster ND, Dun W, Wright PJ, Cardona N, Qian L, Mitchell CC, Boyden PA, Binkley PF, Li C, Anderson ME, Mohler PJ, Hund TJ. Ca2+/calmodulin-dependent protein kinase II-based regulation of voltage-gated Na+ channel in cardiac disease. Circulation. 2012 Oct 23;126(17):2084-94. doi: 10.1161/CIRCULATIONAHA.112.105320. Epub 2012 Sep 24. PubMed PMID: 23008441.

Fischer TH, Maier LS, Sossalla S. The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis. Heart Fail Rev. 2012 Aug 30. [Epub ahead of print] PubMed PMID: 22932727.

Wagner S, Rokita AG, Anderson ME, Maier LS. Redox regulation of sodium and calcium handling. Antioxid Redox Signal. 2013 Mar 20;18(9):1063-77. doi: 10.1089/ars.2012.4818. Epub 2012 Oct 3. PubMed PMID: 22900788; PubMed Central PMCID: PMC3567778.

Mohamed BA, Barakat AZ, Zimmermann WH, Bittner RE, Mühlfeld C, Hünlich M, Engel W, Maier LS, Adham IM. Targeted disruption of Hspa4 gene leads to cardiac hypertrophy and fibrosis. J Mol Cell Cardiol. 2012 Oct;53(4):459-68. doi: 10.1016/j.yjmcc.2012.07.014. Epub 2012 Aug 1. PubMed PMID: 22884543.

Bourgonje VJ, Schoenmakers M, Beekman JD, van der Nagel R, Houtman MJ, Miedema LF, Antoons G, Sipido K, de Windt LJ, van Veen TA, Vos MA. Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog. Heart Rhythm. 2012 Nov;9(11):1875-83. doi: 10.1016/j.hrthm.2012.07.023. Epub 2012 Jul 27. PubMed PMID: 22846339.

Wu Y, Luczak ED, Lee EJ, Hidalgo C, Yang J, Gao Z, Li J, Wehrens XH, Granzier H, Anderson ME. CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban. J Mol Cell Cardiol. 2012 Sep;53(3):429-36. doi: 10.1016/j.yjmcc.2012.06.019. Epub 2012 Jul 11. PubMed PMID: 22796260.

Guo T, Zhang T, Ginsburg KS, Mishra S, Brown JH, Bers DM. CaMKIIδC slows [Ca]i decline in cardiac myocytes by promoting Ca sparks. Biophys J. 2012 Jun 6;102(11):2461-70. doi: 10.1016/j.bpj.2012.04.015. Epub 2012 Jun 5. PubMed PMID: 22713561; PubMed Central PMCID: PMC3368151.

Swaminathan PD, Purohit A, Hund TJ, Anderson ME. Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias. Circ Res. 2012 Jun 8;110(12):1661-77. doi: 10.1161/CIRCRESAHA.111.243956. Review. PubMed PMID: 22679140.

Ashpole NM, Herren AW, Ginsburg KS, Brogan JD, Johnson DE, Cummins TR, Bers DM, Hudmon A. Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. J Biol Chem. 2012 Jun 8;287(24):19856-69. doi: 10.1074/jbc.M111.322537. Epub 2012 Apr 18. PubMed PMID: 22514276; PubMed Central PMCID: PMC3370170.

Respress JL, van Oort RJ, Li N, Rolim N, Dixit SS, deAlmeida A, Voigt N, Lawrence WS, Skapura DG, Skårdal K, Wisløff U, Wieland T, Ai X, Pogwizd SM, Dobrev D, Wehrens XH. Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res. 2012 May 25;110(11):1474-83. doi: 10.1161/CIRCRESAHA.112.268094. Epub 2012 Apr 17. PubMed PMID: 22511749; PubMed Central PMCID: PMC3371642.

Voigt N, Li N, Wang Q, Wang W, Trafford AW, Abu-Taha I, Sun Q, Wieland T, Ravens U, Nattel S, Wehrens XH, Dobrev D. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012 May 1;125(17):2059-70. doi: 10.1161/CIRCULATIONAHA.111.067306. Epub 2012 Mar 28. PubMed PMID: 22456474.

Maier LS. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in the heart. Adv Exp Med Biol. 2012;740:685-702. doi: 10.1007/978-94-007-2888-2_30. Review. PubMed PMID: 22453965.

Singh MV, Swaminathan PD, Luczak ED, Kutschke W, Weiss RM, Anderson ME. MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction. J Mol Cell Cardiol. 2012 May;52(5):1135-44. doi: 10.1016/j.yjmcc.2012.01.021. Epub 2012 Feb 3. PubMed PMID: 22326848; PubMed Central PMCID: PMC3327770.

Li N, Wang T, Wang W, Cutler MJ, Wang Q, Voigt N, Rosenbaum DS, Dobrev D, Wehrens XH. Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice. Circ Res. 2012 Feb 3;110(3):465-70. doi: 10.1161/CIRCRESAHA.111.253229. Epub 2011 Dec 8. PubMed PMID: 22158709; PubMed Central PMCID: PMC3272138.


2011	

Li N, Wang T, Wang W, Cutler MJ, Wang Q, Voigt N, Rosenbaum DS, Dobrev D,
Wehrens XH. Inhibition of CaMKII phosphorylation of RyR2 prevents induction of
atrial fibrillation in FKBP12.6 knockout mice. Circ Res. 2012 Feb
3;110(3):465-70. doi: 10.1161/CIRCRESAHA.111.253229. Epub 2011 Dec 8. PubMed
PMID: 22158709; PubMed Central PMCID: PMC3272138.

He BJ, Joiner ML, Singh MV, Luczak ED, Swaminathan PD, Koval OM, Kutschke W,
Allamargot C, Yang J, Guan X, Zimmerman K, Grumbach IM, Weiss RM, Spitz DR,
Sigmund CD, Blankesteijn WM, Heymans S, Mohler PJ, Anderson ME. Oxidation of
CaMKII determines the cardiotoxic effects of aldosterone. Nat Med. 2011 Nov
13;17(12):1610-8. doi: 10.1038/nm.2506. PubMed PMID: 22081025; PubMed Central
PMCID: PMC3332099.

Said M, Becerra R, Valverde CA, Kaetzel MA, Dedman JR, Mundiña-Weilenmann C,
Wehrens XH, Vittone L, Mattiazzi A. Calcium-calmodulin dependent protein kinase
II (CaMKII): a main signal responsible for early reperfusion arrhythmias. J Mol
Cell Cardiol. 2011 Dec;51(6):936-44. doi: 10.1016/j.yjmcc.2011.08.010. Epub 2011
Aug 19. PubMed PMID: 21888910; PubMed Central PMCID: PMC3208750.

Erickson JR, Patel R, Ferguson A, Bossuyt J, Bers DM. Fluorescence resonance
energy transfer-based sensor Camui provides new insight into mechanisms of
calcium/calmodulin-dependent protein kinase II activation in intact
cardiomyocytes. Circ Res. 2011 Sep 16;109(7):729-38. doi:
10.1161/CIRCRESAHA.111.247148. Epub 2011 Aug 11. PubMed PMID: 21835909; PubMed
Central PMCID: PMC3182829.

Sag CM, Köhler AC, Anderson ME, Backs J, Maier LS. CaMKII-dependent SR Ca leak
contributes to doxorubicin-induced impaired Ca handling in isolated cardiac
myocytes. J Mol Cell Cardiol. 2011 Nov;51(5):749-59. doi:
10.1016/j.yjmcc.2011.07.016. Epub 2011 Jul 26. PubMed PMID: 21819992; PubMed
Central PMCID: PMC3226826

Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He
BJ, Luczak ED, Joiner ML, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM,
Ogawa M, Chen PS, Efimov I, Dobrev D, Mohler PJ, Hund TJ, Anderson ME. Oxidized
CaMKII causes cardiac sinus node dysfunction in mice. J Clin Invest. 2011
Aug;121(8):3277-88. doi: 10.1172/JCI57833. Epub 2011 Jul 25. PubMed PMID:
21785215; PubMed Central PMCID: PMC3223923.

Erickson JR, He BJ, Grumbach IM, Anderson ME. CaMKII in the Cardiovascular
System: Sensing Redox States. Physiol Rev. 2011 Jul;91(3):889-915. PubMed PMID:
21742790.

Saucerman JJ, Bers DM. Calmodulin binding proteins provide domains of local
Ca(2+) signaling in cardiac myocytes. J Mol Cell Cardiol. 2011 Jun 12. [Epub
ahead of print] PubMed PMID: 21708171.

O'Hara T, Virág L, Varró A, Rudy Y. Simulation of the undiseased human cardiac
ventricular action potential: model formulation and experimental validation. PLoS
Comput Biol. 2011 May;7(5):e1002061. Epub 2011 May 26. PubMed PMID: 21637795;
PubMed Central PMCID: PMC3102752.

Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM,
Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J,
Robbins J. A critical function for ser-282 in cardiac Myosin binding protein-C
phosphorylation and cardiac function. Circ Res. 2011 Jul 8;109(2):141-50. Epub
2011 May 19. PubMed PMID: 21597010; PubMed Central PMCID: PMC3132348.

Gao Z, Singh MV, Hall DD, Koval OM, Luczak ED, Joiner ML, Chen B, Wu Y,
Chaudhary AK, Martins JB, Hund TJ, Mohler PJ, Song LS, Anderson ME.
Catecholamine-Independent Heart Rate Increases Require Ca2+/Calmodulin-Dependent
Protein Kinase II. Circ Arrhythm Electrophysiol. 2011 Jun 1;4(3):379-87. Epub
2011 Mar 15. PubMed PMID: 21406683; PubMed Central PMCID: PMC3116039.

Rokita AG, Sag CM, Maier LS. [Heart failure. Excitation-contraction coupling
and novel therapeutic options]. Herz. 2011 Mar;36(2):94-101. German. PubMed PMID:
21286671.

Singh MV, Anderson ME. Is CaMKII a link between inflammation and hypertrophy
in heart? J Mol Med (Berl). 2011 Jun;89(6):537-43. Epub 2011 Jan 29. PubMed PMID:
21279501.

Anderson ME, Brown JH, Bers DM. CaMKII in myocardial hypertrophy and heart
failure. J Mol Cell Cardiol. 2011 Jan 27. [Epub ahead of print] PubMed PMID:
21276796.

Bers DM. Ca(2+)-calmodulin-dependent protein kinase II regulation of cardiac
excitation-transcription coupling. Heart Rhythm. 2011 Jul;8(7):1101-4. Epub 2011
Jan 18. PubMed PMID: 21255680; PubMed Central PMCID: PMC3129479.

Wagner S, Ruff HM, Weber SL, Bellmann S, Sowa T, Schulte T, Anderson ME,
Grandi E, Bers DM, Backs J, Belardinelli L, Maier LS. Reactive oxygen
species-activated Ca/calmodulin kinase IIδ is required for late I(Na)
augmentation leading to cellular Na and Ca overload. Circ Res. 2011 Mar
4;108(5):555-65. Epub 2011 Jan 20. PubMed PMID: 21252154; PubMed Central PMCID:
PMC3065330.

Dybkova N, Sedej S, Napolitano C, Neef S, Rokita AG, Hünlich M, Brown JH,
Kockskämper J, Priori SG, Pieske B, Maier LS. Overexpression of CaMKIIδc in
RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and
increased mortality. J Am Coll Cardiol. 2011 Jan 25;57(4):469-79. PubMed PMID:
21251589.

Sossalla S, Maurer U, Schotola H, Hartmann N, Didié M, Zimmermann WH,
Jacobshagen C, Wagner S, Maier LS. Diastolic dysfunction and arrhythmias caused
by overexpression of CaMKIIδ(C) can be reversed by inhibition of late Na(+)
current. Basic Res Cardiol. 2011 Mar;106(2):263-72. Epub 2010 Dec 21. PubMed
PMID: 21174213; PubMed Central PMCID: PMC3032905.

Huke S, Desantiago J, Kaetzel MA, Mishra S, Brown JH, Dedman JR, Bers DM.
SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac
remodeling in mice overexpressing CaMKIIδC. J Mol Cell Cardiol. 2011
Jan;50(1):230-8. Epub 2010 Oct 21. PubMed PMID: 20971119; PubMed Central PMCID:
PMC3018844.

Liu N, Ruan Y, Denegri M, Bachetti T, Li Y, Colombi B, Napolitano C, Coetzee
WA, Priori SG. Calmodulin kinase II inhibition prevents arrhythmias in
RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia.
J Mol Cell Cardiol. 2011 Jan;50(1):214-22. Epub 2010 Oct 23. PubMed PMID:
20937285.

Wehrens XH. CaMKII regulation of the cardiac ryanodine receptor and
sarcoplasmic reticulum calcium release. Heart Rhythm. 2011 Feb;8(2):323-5. Epub
2010 Sep 29. PubMed PMID: 20887810; PubMed Central PMCID: PMC3020993.

Maier LS. CaMKII regulation of voltage-gated sodium channels and cell
excitability. Heart Rhythm. 2011 Mar;8(3):474-7. Epub 2010 Sep 29. PubMed PMID:
20887805.

Seidler T, Teucher N, Hellenkamp K, Unsöld B, Grebe C, Kramps P, Schotola H,
Wagner S, Schöndube FA, Hasenfuss G, Maier LS. Limitations of FKBP12.6-directed
treatment strategies for maladaptive cardiac remodeling and heart failure. J Mol
Cell Cardiol. 2011 Jan;50(1):33-42. Epub 2010 Aug 24. PubMed PMID: 20797399.

Mohler PJ, Hund TJ. Role of CaMKII in cardiovascular health, disease, and
arrhythmia. Heart Rhythm. 2011 Jan;8(1):142-4. Epub 2010 Jul 29. Review. PubMed
PMID: 20673813; PubMed Central PMCID: PMC2988944.

 

2010

Sossalla S, Maurer U, Schotola H, Hartmann N, Didié M, Zimmermann WH,
Jacobshagen C, Wagner S, Maier LS. Diastolic dysfunction and arrhythmias caused
by overexpression of CaMKIIδ(C) can be reversed by inhibition of late Na (+)
current. Basic Res Cardiol. 2010 Dec 21. [Epub ahead of print] PubMed PMID:
21174213.

van Oort RJ, McCauley MD, Dixit SS, Pereira L, Yang Y, Respress JL, Wang Q, De
Almeida AC, Skapura DG, Anderson ME, Bers DM, Wehrens XH. Ryanodine receptor
phosphorylation by calcium/calmodulin-dependent protein kinase II promotes
life-threatening ventricular arrhythmias in mice with heart failure. Circulation.
2010 Dec 21;122(25):2669-79. Epub 2010 Nov 15. PubMed PMID: 21098440.

Bers DM. CaMKII inhibition in heart failure makes jump to human. Circ Res.
2010 Oct 29;107(9):1044-6. Review. PubMed PMID: 21030721.

Huke S, Desantiago J, Kaetzel MA, Mishra S, Brown JH, Dedman JR, Bers DM.
SR-targeted CaMKII inhibition improves SR Ca(2+) handling, but accelerates
cardiac remodeling in mice overexpressing CaMKIIδ(C). J Mol Cell Cardiol. 2010
Oct 21. [Epub ahead of print] PubMed PMID: 20971119.

Liu N, Ruan Y, Denegri M, Bachetti T, Li Y, Colombi B, Napolitano C, Coetzee
WA, Priori SG. Calmodulin kinase II inhibition prevents arrhythmias in
RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia.
J Mol Cell Cardiol. 2010 Oct 23. [Epub ahead of print] PubMed PMID: 20937285.

Wehrens XH. CaMKII regulation of the cardiac ryanodine receptor and
sarcoplasmic reticulum calcium release. Heart Rhythm. 2010 Sep 29. [Epub ahead of
print] PubMed PMID: 20887810.

Maier LS. CaMKII regulation of voltage-gated sodium channels and cell
excitability. Heart Rhythm. 2010 Sep 29. [Epub ahead of print] PubMed PMID:
20887805.

Hund TJ, Koval OM, Li J, Wright PJ, Qian L, Snyder JS, Gudmundsson H, Kline
CF, Davidson NP, Cardona N, Rasband MN, Anderson ME, Mohler PJ. A
β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in
mice. J Clin Invest. 2010 Oct 1;120(10):3508-19. doi: 10.1172/JCI43621. Epub 2010
Sep 27. PubMed PMID: 20877009; PubMed Central PMCID: PMC2947241.

Sossalla S, Fluschnik N, Schotola H, Ort KR, Neef S, Schulte T, Wittköpper K,
Renner A, Schmitto JD, Gummert J, El-Armouche A, Hasenfuss G, Maier LS.
Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves
contractility in human failing myocardium. Circ Res. 2010 Oct 29;107(9):1150-61.
Epub 2010 Sep 2. PubMed PMID: 20814023.

Seidler T, Teucher N, Hellenkamp K, Unsöld B, Grebe C, Kramps P, Schotola H,
Wagner S, Schöndube FA, Hasenfuss G, Maier LS. Limitations of FKBP12.6-directed
treatment strategies for maladaptive cardiac remodeling and heart failure. J Mol
Cell Cardiol. 2010 Aug 24. [Epub ahead of print] PubMed PMID: 20797399.

Toischer K, Rokita AG, Unsöld B, Zhu W, Kararigas G, Sossalla S, Reuter SP,
Becker A, Teucher N, Seidler T, Grebe C, Preuss L, Gupta SN, Schmidt K, Lehnart
SE, Krüger M, Linke WA, Backs J, Regitz-Zagrosek V, Schäfer K, Field LJ, Maier
LS, Hasenfuss G. Differential cardiac remodeling in preload versus afterload.
Circulation. 2010 Sep 7;122(10):993-1003. Epub 2010 Aug 23. PubMed PMID:
20733099; PubMed Central PMCID: PMC2955196.

Dobrev D, Wehrens XH. Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak,
and atrial fibrillation. Trends Cardiovasc Med. 2010 Jan;20(1):30-4. Review.
PubMed PMID: 20685575; PubMed Central PMCID: PMC2917388.

Aye TT, Scholten A, Taouatas N, Varro A, Van Veen TA, Vos MA, Heck AJ.
Proteome-wide protein concentrations in the human heart. Mol Biosyst. 2010 Oct
1;6(10):1917-27. Epub 2010 Jul 1. PubMed PMID: 20596566.

Mishra S, Ling H, Grimm M, Zhang T, Bers DM, Brown JH. Cardiac Hypertrophy
and Heart Failure Development Through Gq and CaM Kinase II Signaling. J
Cardiovasc Pharmacol. 2010 Jun 7. [Epub ahead of print] PubMed PMID: 20531218;
PubMed Central PMCID: PMC2947575.

Curran J, Brown KH, Santiago DJ, Pogwizd S, Bers DM, Shannon TR. Spontaneous
Ca waves in ventricular myocytes from failing hearts depend on
Ca(2+)-calmodulin-dependent protein kinase II. J Mol Cell Cardiol. 2010
Jul;49(1):25-32. Epub 2010 Mar 29. PubMed PMID: 20353795; PubMed Central PMCID:
PMC2883657.

Bers DM. Calcium channels are ganging up in the sarcolemma. Circ Res. 2010
Mar 5;106(4):625-6. PubMed PMID: 20203310; PubMed Central PMCID: PMC2839079.

Koval OM, Guan X, Wu Y, Joiner ML, Gao Z, Chen B, Grumbach IM, Luczak ED,
Colbran RJ, Song LS, Hund TJ, Mohler PJ, Anderson ME. CaV1.2 beta-subunit
coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations. Proc
Natl Acad Sci U S A. 2010 Mar 16;107(11):4996-5000. Epub 2010 Mar 1. PubMed PMID:
20194790; PubMed Central PMCID: PMC2841943.

Sipido KR, Vangheluwe P. Targeting sarcoplasmic reticulum Ca2+ uptake to
improve heart failure: hit or miss. Circ Res. 2010 Feb 5;106(2):230-3. PubMed
PMID: 20133907.

Schott P, Jacobshagen C, Köhler J, Seidler T, Asif AR, Dihazi H, Hasenfuss G,
Maier LS. Proteome changes in CaMKIIδC-overexpressing cardiac myocytes.
Cardiovasc Pathol. 2010 Nov-Dec;19(6):e241-50. Epub 2010 Jan 25. PubMed PMID:
20093047.

Neef S, Dybkova N, Sossalla S, Ort KR, Fluschnik N, Neumann K, Seipelt R,
Schöndube FA, Hasenfuss G, Maier LS. CaMKII-dependent diastolic SR Ca2+ leak and
elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial
fibrillation. Circ Res. 2010 Apr 2;106(6):1134-44. Epub 2010 Jan 7. PubMed PMID:
20056922.

Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers DM, Brown
JH. Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but
exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res. 2010
Feb 5;106(2):354-62. Epub 2009 Dec 3. PubMed PMID: 19959778; PubMed Central
PMCID: PMC2818826.

 

2009

Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009 Jul;119(7):1940-51. PubMed PMID: 19603549; PubMed Central PMCID: PMC2701862.

Han F, Tucker AL, Lingrel JB, Despa S, Bers DM. Extracellular Potassium Dependence of the Na+/K+-ATPase in Cardiac Myocytes; Isoform Specificity and Effect of Phospholemman. Am J Physiol Cell Physiol. 2009 Jul 1. [Epub ahead of print] PubMed PMID: 19570895.

Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5972-7. Epub 2009 Mar 10. PubMed PMID: 19276108; PubMed Central PMCID: PMC2667018.

Ruan Y, Liu N, Priori SG. Sodium channel mutations and arrhythmias. Nat Rev Cardiol. 2009 May;6(5):337-48. Review. PubMed PMID: 19377496.

Anderson ME. CaMKII and a failing strategy for growth in heart. J Clin Invest. 2009 May;119(5):1082-5. PubMed PMID: 19422097; PubMed Central PMCID: PMC2673844.

Dadvar P, O'Flaherty M, Scholten A, Rumpel K, Heck AJ. A chemical proteomics based enrichment technique targeting the interactome of the PDE5 inhibitor PF-4540124. Mol Biosyst. 2009 May;5(5):472-82. Epub 2009 Mar 13. PubMed PMID: 19381362.

Andrienko TN, Picht E, Bers DM. Mitochondrial free calcium regulation during sarcoplasmic reticulum calcium release in rat cardiac myocytes. J Mol Cell Cardiol. 2009 Jun;46(6):1027-36. Epub 2009 Apr 1. PubMed PMID: 19345225; PubMed Central PMCID: PMC2683203.

Singh MV, Kapoun A, Higgins L, Kutschke W, Thurman JM, Zhang R, Singh M, Yang J, Guan X, Lowe JS, Weiss RM, Zimmermann K, Yull FE, Blackwell TS, Mohler PJ, Anderson ME. Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. J Clin Invest. 2009 Apr;119(4):986-96. doi: 10.1172/JCI35814. Epub 2009 Mar 9. PubMed PMID: 19273909; PubMed Central PMCID: PMC2662543.

Ideker RE, Kong W, Pogwizd S. Purkinje fibers and arrhythmias. Pacing Clin Electrophysiol. 2009 Mar;32(3):283-5. PubMed PMID: 19272054. Backs J, Backs T, Neef S, Kreusser MM, Lehmann LH, Patrick DM, Grueter CE, Qi X, Richardson JA, Hill JA, Katus HA, Bassel-Duby R, Maier LS, Olson EN. The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2342-7. Epub 2009 Jan 28. PubMed PMID: 19179290; PubMed Central PMCID: PMC2650158.

Decker KF, Heijman J, Silva JR, Hund TJ, Rudy Y. Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium. Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H1017-26. Epub 2009 Jan 23. PubMed PMID: 19168720; PubMed Central PMCID: PMC2670702.

Anderson ME, Mohler PJ. Rescuing a failing heart: think globally, treat locally. Nat Med. 2009 Jan;15(1):25-6. PubMed PMID: 19129780.

Aye TT, Mohammed S, van den Toorn HW, van Veen TA, van der Heyden MA, Scholten A, Heck AJ. Selectivity in enrichment of cAMP-dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins. Mol Cell Proteomics. 2009 May;8(5):1016-28. Epub 2008 Dec 31. PubMed PMID: 19119138; PubMed Central PMCID: PMC2689760.

Vincent GM, Schwartz PJ, Denjoy I, Swan H, Bithell C, Spazzolini C, Crotti L, Piippo K, Lupoglazoff JM, Villain E, Priori SG, Napolitano C, Zhang L. High efficacy of beta-blockers in long-QT syndrome type 1: contribution of noncompliance and QT-prolonging drugs to the occurrence of beta-blocker treatment"failures". Circulation. 2009 Jan 20;119(2):215-21. Epub 2008 Dec 31. PubMed PMID: 19118258.

Donahue JK. Novel strategy to reduce sudden-death risk in the healing phase after myocardial infarction. Circulation. 2009 Jan 6;119(1):6-8. Epub 2008 Dec 22. PubMed PMID: 19103983.

Fernández-Velasco M, Rueda A, Rizzi N, Benitah JP, Colombi B, Napolitano C, Priori SG, Richard S, Gómez AM. Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia. Circ Res. 2009 Jan 30;104(2):201-9, 12p following 209. Epub 2008 Dec 18. PubMed PMID: 19096022.

Hund TJ, Wright PJ, Dun W, Snyder JS, Boyden PA, Mohler PJ. Regulation of the ankyrin-B-based targeting pathway following myocardial infarction. Cardiovasc Res. 2009 Mar 1;81(4):742-9. Epub 2008 Dec 14. PubMed PMID: 19074823; PubMed Central PMCID: PMC2642599.

Johnson JN, Hofman N, Haglund CM, Cascino GD, Wilde AA, Ackerman MJ. Identification of a possible pathogenic link between congenital long QT syndrome and epilepsy. Neurology. 2009 Jan 20;72(3):224-31. Epub 2008 Nov 26. PubMed PMID: 19038855; PubMed Central PMCID: PMC2677528.

Sasano T, Kelemen K, Greener ID, Donahue JK. Ventricular tachycardia from the healed myocardial infarction scar: validation of an animal model and utility of gene therapy. Heart Rhythm. 2009 Aug;6(8 Suppl):S91-7. Epub 2009 Apr 1. PubMed PMID: 19631912.

Silva JR, Pan H, Wu D, Nekouzadeh A, Decker KF, Cui J, Baker NA, Sept D, Rudy Y. A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential. Proc Natl Acad Sci U S A. 2009 July. 7;106(27):11102-6. Epub 2009 Jun 22. PubMed PMID: 19549851; PubMed Central PMCID: PMC2700153.

Backs J, Backs T, Neef S, Kreusser MM, Lehmann LH, Patrick DM, Grueter CE, Qi X, Richardson JA, Hill JA, Katus HA, Bassel-Duby R, Maier LS, Olson EN. The delta isoform of CaM Kinase II is required for pathological cardiac hypertrophy and modeling after pressure overload. Proc Natl Acad Sci U S A. 106;2342-2347.2009

Wagner S, Hacker E, Grandi E, Weber SL, Dybkova N, Sossalla S, Sowa T, Bers DM, Maier LS. Ca/calmodulin kinase II differentially modulates potassium currents. Circ Arrhythmia Electophysiol. 2;285-294.2009

Sag Cm, Wadsack DP. Khabbazzadeh S, Abesser M, Grefe C, neef S, Maier SKG, Maier LS. CaMKII Contributes to cardiac arrhythmogenesis in transgenic CaMKIIdeltaC mice having heart failure. Circ Heart Fail. 2:664-75.2009.

 

2008

(Selected publications out of > 50. Follow link for complete list on Pubmed.)

Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Barlett RK, Lowe JS, O'Donnell SE, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AJ, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME. A dynamic pathway for calcium-independent activation of CaMKII by methione oxidation. Cell. 2008 May 2;133(3):462-74.

Huke S, Bers DM. Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. Biochem Biophys Res Commun. 2008 Aug 25.

Bierhuizen MF, Boulaksil M, van Stuijvenberg L, van der Nagel R, Jansen AT, Mutsaers NA, Yildrim C, van Veen TA, de Windt LJ, Vos MA, van Rijen HV. In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms. J Mol Cell Cardiol. 2008 Jul 11.

Hund TJ, Decker KF, Kanter E, Mohler PJ, Boyden PA, Schuessler RB, Yamada KA, Rudy Y. Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: Insights from mathematical modeling. J Mol Cell Cardiol. 2008.

Desantiago J, Ai X, Islam M, Acuna G, Ziolo MT, Bers DM, Pogwizd SM. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 6;102(11):1389-97.

Ozdemir S, Bito V, Holemans P, Vinet L, Mercadier J, Varro A, Sipido KR. Pharmacological inhibition of Na/Ca exchange results in increased cellular Ca2+ load attributable to the predominance of forward mode block. Circ Res. 2008 Jun 6;102(11):1398-405.

Werdich AA, Lima EA, Dzhura I, Singh MV, Li J, Anderson ME, Baudenbacher FJ. Differential effects of phospholamban and Ca2+/calmodulin-dependent kinase II on [Ca2+]i-transients in cardiac myocytes at physiological stimulation frequencies. Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2352-62.

Chen PS and Priori SG. The Brugada syndrome. J Am Coll Cardiol. 2008;51:1176-80.

Mohler PJ and Anderson ME. New insights into genetic causes of sinus node dysfunction and atrial fibrillation. J Cardiovasc Electrophys. 2008 May;19(5):516-8.

Scholten A, Aye TT, Heck AJ. A multi-angular mass spectrometric view at cyclic nucleotide dependent protein kinases: In vivo characterization and structure/function relationships. Mass Spectrom Rev. 2008 Jul-Aug;27(4):331-53.

Kelly EM, Hou Z, Bossuyt J, Bers DM, Robia SL. Phospholamban oligomerization, quaternary structure, and SERCA-binding measured by FRET in living cells. J Biol Chem. 2008.

Boveri L, Priori SG. Molecular strategies for the electrophysiologist. Nat Clin Pract Cardiovasc Med. 2008 Mar;5(3):117.

Kline CF, Cunha SR, Lowe JS, Hund TJ, Mohler PJ. Revisiting ankyrin-InsP(3) receptor interactions: Ankyrin-B associates with the cytoplasmic N-terminus of the InsP(3) receptor. J Cell Biochem. 2008.

Bossuyt J, Helmstadter K, Wu X, Clements-Jewery H, Haworth RS, Avkiran M, Martin J, Pogwizd SM, Bers DM. Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Circ Res. 2008 Mar;102(6):695-702.

El Yaman M, Perry J, Makielski JC, Ackerman MJ. Suppression of atrial fibrillation with mexiletine pharmacotherapy in a young woman with type 1 long QT syndrome. Heart Rhythm. 2008 Mar;5(3):472-4.

Jansen JA, de Boer TP, Wolswinkel R, van Veen TA, Vos MA ,van Rijen HV, van der Heyden MA. Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density. Biochem Biophys Fes Commun. 2008 Mar 14;367(3):687-92.

Lowe JS, Palygin O, Bhasin N, Hund TJ, Boyden PA, Shibata E, Anderson ME, Mohler PJ. Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway. J Cell Biol. 2008 Jan 14;180(1):173-86.

Hinterseer M, Thomsen MB, Beckmann BM, Pfeufer A, Schimpf R, Wichmann HE, Steinbeck G, Vos MA, Kaab S. Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study. Eur Heart J. 2008 Jan;29(2):185-90.

Kockskamper J, Seidlmayer L, Walther S, Hellenkamp K, Maier LS, Pieske B. Endothelin-1 enhances nuclear Ca2+ transients in atrial myocytes through Ins(1,4,5)P3-dependent Ca2+ release from perinuclear Ca2+ stores. J Cell Sci. 2008 Jan 15;121:186-95.

Khoo MS, Grueter CE, Eren M, Yang J, Zhang R, Bass MA, Lwin ST, Mendes LA, Vaughan DE, Colbran RJ, Anderson ME. Calmodulin kinase II inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein. J Mol Cell Cardiol. 2008 Feb;44(2):405-10.

 

2007

(Selected publications out of > 150. Follow link for complete list on Pubmed.)

Zhang T, Kohlhaas M, Backs J, Mishra S, Phillips W. Dybkova N, Chang S, Ling H. Bers DM, Maier LS, Olson EN, Brown JH. CaMKII delta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. J Biol Chem. 2007 Nov 30;282(48):35078-87.

Guo T, Ai X, Shannon TR, Pogwizd SM, Bers DM. Intra-sarcoplasmic reticulum free [Ca2+] and buffering in arrhythmogenic failing rabbit heart. Circ Res. 2007;101:802-10.

Grandi E, Puglisi JL, Wagner S, Maier LS, Severi S, Bers DM. Simulation of Ca/Calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J. 2007 Dec 1;93(11):3835-47.

Maier LS, Bers DM, Brown JH.
Calmodulin and Ca2+/calmodulin kinases in the heart - physiology and pathophysiology.
Cardiovasc Res. 2007 Mar;73:629-30.

Maier LS, Bers DM. Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res. 2007 Mar;73:631-40.

Lehnart SE, Ackerman MJ, Benson DW Jr, Brugada R, Clancy CE, Donahue JK, George AL Jr, Grant AO, Groft SC, January CT, Lathrop DA, Lederer WJ, Makielski JC, Mohler PJ, Moss A, Nerbonne JM, Olson TM, Przywara DA, Towbin JA, Wang LH, Marks AR. Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function. Circulation. 2007 Nov 13;116(20):2325-45.

Landstrom AP, Weisleder N, Batalden KB, Bos JM, Tester DJ, Ommen SR, Wehrens XH, Claycomb WC, Ko JK, Hwang M, Pan Z, Ma J, Ackerman MJ. Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. J Mol Cell Cardiol. 2007 Jun;42(6):1026-35.

Seth R, Moss AJ, McNitt S, Zareba W, Andrews ML, Qi M, Robinson JL, Goldenberg I, Ackerman MJ, Benhorin J, Kaufman ES, Locati EH, Napolitano C, Priori SG, Schwartz PJ, Towbin JA, Vincent GM, Zhang L. Long QT syndrome and pregnancy. J Am Coll Cardiol. 2007 Mar 13;49(10):1092-8.

Mohler PJ and Wehrens XH. Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions. Physiology (Bethesda). 2007 Oct;22:342-50.

Anderson ME, Mohler PJ. MicroRNA may have macro effect on sudden death. Nat Med. 2007 Apr;13:410-1.

Anderson ME. Multiple downstream proarrhythmic targets for calmodulin kinase II: moving beyond an ion channel-centric focus. Cardiovasc Res. 2007; 16;122:185-9.

Ruan Y, Liu N, Bloise R, Napolitano C, Priori SG. Gating properties of SCN5A mutations and the response to mexiletine in long-QT syndrome type 3 patients. Circulation 2007 Sep;116:1137-44.

Napolitano C, Priori SG. Diagnosis and treatment of catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm 2007 May;4:675-8.

Sauer AJ, Moss AJ, McNitt S, Zareba W, Robinson JL, QI M, Goldenberg I, Hobbs JB, Ackerman MJ, Benhorin J, Hall WJ, Kaufman ES, Locatis EH, Napolitano C, Priori SG, Schwartz PJ, Towbin JA, Vincent GM, Zhang L. Long QT syndrome in adults. J Am Coll Cardiol. 2007 Jan;49:329-37.

Sipido KR, Bito V, Antoons G, Volders PG, Vos MA. Na/Ca exchange and cardiac ventricular arrhythmias. Ann N Y Acad Sci. 2007 Mar;1099:339-48.

Antoons G, Oros A, Bito V, Sipido KR, Vos MA.Cellular basis for triggered ventricular arrhythmias that occur in the setting of compensated hypertrophy and heart failure: considerations for diagnosis and treatment. J Electrocardiol. 2007 Nov-Dec;40(6 Suppl):S8-14.

Antoons G, Volders PG, Stankovicova T, Bito V, Stengl M, Vos MA, Sipido KR.
Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block. J Physiol. 2007 Feb 15;579(Pt 1):147-60.

Scholten A, van Veen TA, Vos MA, Heck AJ. Diversity of cAMP-dependent protein kinase isoforms and their anchoring proteins in mouse ventricular tissue. J Proteome Res. 2007 May;6(5):1705-17.

 

2006

Khoo MS, Li J, Singh MV, Yang Y, Kannankeril P, Wu Y, Grueter CE, Guan X, Oddis CV, Zhang R, Mendes L, Ni G, Madu EC, Yang J, Bass M, Gomez RJ, Wadzinski BE, Olson EN, Colbran RJ, Anderson ME. Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy. Circulation 2006;114:1352-9.

Li J, Marionneau C, Zhang R, Shah V, Hell JW, Nerbonne JM, Anderson ME. Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents. Circ Res. 2006;99:1092-9.

Sasano T, McDonald AD, Kikuchi K, Donahue JK. Molecular ablation of ventricular tachycardia after myocardial infarction. Nat Med. 2006 November;12:1256-8.

Grueter CE, Abiria SA, Dzhura I, Wu Y, Ham AJ, Mohler PJ, Anderson ME, Colbran RJ. L-Type Ca2+ Channel Facilitation Mediated by Phosphorylation of the beta Subunit by CaMKII. Mol Cell. 2006 September 1;23:641-50.

Anderson ME, Higgins LS, Schulman H. Disease mechanisms and emerging therapies: protein kinases and their inhibitors in myocardial disease. Nat Clin Pract Cardiovasc Med. 2006;3:437-45.

Wu Y, Shintani A, Grueter C, Zhang R, Hou Y, Yang J, Kranias EG, Colbran RJ, Anderson ME. Suppression of dynamic Ca2+ transient responses to pacing in ventricular myocytes from mice with genetic calmodulin kinase II inhibition. J Mol Cell Cardiol. 2006 Feb;40:213-23.

Scholten A, Poh MK, van Veen TA, van BB, Vos MA, Heck AJ. Analysis of the cGMP/cAMP interactome using a chemical proteomics approach in mammalian heart tissue validates sphingosine kinase type 1-interacting protein as a genuine and highly abundant AKAP 8. J Proteome Res 2006 June;5:1435-47.

 

2005

Zhang R, Khoo MS, Wu Y, Yang Y, Grueter CE, Ni G, Price EE, Thiel W, Guatimosim S, Song LS, Madu EC, Shah AN, Vishnivetskaya TA, Atkinson JB, Gurevich VV, Salama G, Lederer WJ, Colbran RJ, Anderson ME. Calmodulin kinase II inhibition protects against structural heart disease. Nat Med. 2005 Apr;11:409-17.

Anderson ME. Calmodulin kinase signaling in heart: an intriguing candidate target for therapy of myocardial dysfunction and arrhythmias. Pharmacol Ther. 2005;106:39-55.

Cerrone M, Colombi B, Santoro M, di Barletta MR, Scelsi M, Villani L, Napolitano C, Priori SG. Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor. Circ Res. 2005;96:e77-e82.

Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM. Ca2+-calmodulin-dependent protein kinase modulates RyR2 pohsphorylation and SR Ca2+ leak in heart failure. Circ Res. 2005 Dec;97:1314-22.

Bers DM. Beyond beta blockers. Nat Med. 2005 April;11:379-80.

 

2004

Wehrens XH, Lehnart SE, Reiken SR, Marks AR. Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res. 2004 April 2;94:e61-e70.

Mohler PJ, Splawski I, Napolitano C, Bottelli G, Sharpe L, Timothy K, Priori SG, Keating MT, Bennett V. A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. Proc Natl Acad Sci U S A. 2004 ;101:9137-42.

Mohler PJ, Rivolta I, Napolitano C, Lemaillet G, Lambert S, Priori SG, Bennett V. Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. Proc Natl Acad Sci U S A. 2004 December 14;101(50):17533-8.

Thomsen MB, Verduyn SC, Stengl M, Beekman JD, de PG, van OJ, Volders PG, Vos MA. Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs. Circulation 2004;110:2453-9.

Hund TJ, Rudy Y. Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation 2004 November 16;110(20):3168-74.

 

2003

Mohler PJ, Schott JJ, Gramolini AO, Dilly KW, Guatimosim S, duBell WH, Song LS, Haurogne K, Kyndt F, Ali ME, Rogers TB, Lederer WJ, Escande D, Le Marec H, Bennett V. Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature 2003;421:634-9.

Zhang T, Maier LS, Dalton ND, Miyamoto S, Ross J, Jr., Bers DM, Brown JH. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res. 2003;92:912-9.

Maier LS, Zhang T, Chen L, DeSantiago J, Brown JH, Bers DM. Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res. 2003;92:904-11.

 

And Beyond

Wu Y, Temple J, Zhang R, Dzhura I, Zhang W, Trimble RW, Roden DM, Passier R, Olson EN, Colbran RJ, Anderson ME. Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy. Circulation 2002 ;106:1288-93. Maier LS, Bers DM. Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond. J Mol Cell Cardiol. 2002 August;34:919-39.

Pogwizd SM, Schlotthauer K, Li L, Yuan W, Bers DM. Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ Res. 2001;88:1159-67.

Mazur A, Roden DM, Anderson ME. Systemic Administration of Calmodulin Antagonist W-7 or Protein Kinase A Inhibitor H-8 Prevents Torsade de Pointes in Rabbits. Circulation 1999;100:2437-42.