Dr. Rudy’s research aims at understanding the mechanisms that underlie normal and abnormal rhythms of the heart at various levels, from the molecular (ion channel) and cellular to the whole heart. His lab is also developing a novel noninvasive imaging modality (Electrocardiographic Imaging, ECGI) for the diagnosis and guided therapy of cardiac arrhythmias. Through the development of detailed mathematical models of cardiac cells and tissue, he investigates the mechanisms and consequences of genetically-inherited cardiac arrhythmias, impaired cell-to-cell communication, and abnormal spread of the cardiac impulse in the diseased heart (e.g. myocardial infarction). ECGI imaging is currently being tested, evaluated and applied in patients with various heart conditions.

Honors, Awards, and Organizations
Member of the National Academy of Engineering (since 2003)
NIH MERIT Award, 1998
President, the Cardiac Electrophysiology Society, November 2006-November 2008
Fellow of the American Physiological Society
Fellow of the Institute of Electrical and Electronics Engineers (IEEE)
Fellow of the American Institute of Medical and Biological Engineering (AIMBE)
Fellow of the American Heart Association

Recent Publications

Gaur N, Rudy Y. Multiscale modeling of calcium cycling in cardiac ventricular
myocyte: macroscopic consequences of microscopic dyadic function. Biophys J. 2011
Jun 22;100(12):2904-12. PubMed PMID: 21689523; PubMed Central PMCID: PMC3123916.

O'Hara T, Virág L, Varró A, Rudy Y. Simulation of the undiseased human cardiac
ventricular action potential: model formulation and experimental validation. PLoS
Comput Biol. 2011 May;7(5):e1002061. Epub 2011 May 26. PubMed PMID: 21637795;
PubMed Central PMCID: PMC3102752.

Nekouzadeh A, Rudy Y. Continuum molecular simulation of large conformational
changes during ion-channel gating. PLoS One. 2011;6(5):e20186. Epub 2011 May 20.
PubMed PMID: 21625456; PubMed Central PMCID: PMC3098872.

Nekouzadeh A, Rudy Y. Three-residue loop closure in proteins: A new kinematic
method reveals a locus of connected loop conformations. J Comput Chem. 2011
Sep;32(12):2515-25. doi: 10.1002/jcc.21812. Epub 2011 May 26. PubMed PMID:
21618253.

Li P, Rudy Y. A model of canine purkinje cell electrophysiology and Ca2+
cycling: rate dependence, triggered activity, and comparison to ventricular
myocytes. Circ Res. 2011 Jun 24;109(1):71-9. Epub 2011 May 12. PubMed PMID:
21566216.

van Oort RJ, Garbino A, Wang W, Dixit SS, Landstrom AP, Gaur N, De Almeida AC,
Skapura DG, Rudy Y, Burns AR, Ackerman MJ, Wehrens XH. Disrupted junctional
membrane complexes and hyperactive ryanodine receptors after acute junctophilin
knockdown in mice. Circulation. 2011 Mar 8;123(9):979-88. Epub 2011 Feb 21.
PubMed PMID: 21339484; PubMed Central PMCID: PMC3056402.

Ghosh S, Silva JN, Canham RM, Bowman TM, Zhang J, Rhee EK, Woodard PK, Rudy Y.
Electrophysiologic substrate and intraventricular left ventricular dyssynchrony
in nonischemic heart failure patients undergoing cardiac resynchronization
therapy. Heart Rhythm. 2011 May;8(5):692-9. Epub 2011 Jan 11. PubMed PMID:
21232630; PubMed Central PMCID: PMC3096066.