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Match Criteria for Unrelated Stem Cell Donors
There are two levels of testing in identifying an unrelated stem cell donor for you. The first level of testing is basic tissue typing. A potential donor must be listed within a donor registry as either matching your HLA-A, B & DR typing exactly, or they must only match three out of four of your HLA-A and B antigens. Many donor registries have volunteers listed who have been tissue typed at the HLA-A and B antigens only. If your best matched donors have not been DR typed, you and your physicians may elect to have the typing completed. The expense for DR typing is charged to you, the patient, or your insurer.
The second level of testing is confirmatory typing. If one or more donors are identified who meet the above tissue typing criteria, a request is made for those volunteers to have a blood sample drawn and shipped to our lab. We repeat the volunteer's HLA-A & B typing and DR type their cells using DNA technology. At this level, tissue types are completely defined. The donor's blood is also tested for infectious diseases.
Summary of Match Criteria
MATCH CRITERIA - We will accept two groups of unrelated donors:
Group 1 = Unrelated donors who share all of your HLA-A, B & DR antigens. All antigens must be defined using DNA technology.
Group 2 = Unrelated donors who mismatch at only one HLA-A or B antigen. All other HLA-A, B and DR antigens must match.
All antigens must be defined using DNA technology.
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