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ALTAlumni Interviews:
Marion "Dave" Francis, Ph.D.

53PhD
2003 Recipient of Distinguished Alumni Award for Achievement

" I considered Iowa City my hometown for at least three straight years," he said. "I’m very honored to be receiving this award and very pleased. It is nice to go back.""



When Marion "Dave" Francis, Ph.D., arrived in Iowa in 1949, he had a research assistantship waiting and $7.42 in his pocket. When he arrives again in June — his first time back in more than 50 years — he will receive the UI Carver College of Medicine’s Distinguished Alumni Award for Achievement.

The award recognizes his more than 40 years of innovative research at Procter & Gamble, where he made discoveries that benefit millions of people today.

Francis began his education at the University of British Columbia, earning a bachelor’s degree in physics and chemistry with a minor in mathematics, and a master’s degree in analytical chemistry with a minor in physics. Graduate school at the UI led Francis in a new direction — biophysical chemistry. He began his career at Procter & Gamble a year before earning his UI doctorate, joining the company in 1952.

" I was doing research at the Iowa radiation research laboratories when a section head from Procter & Gamble came to the labs and wanted a tour," Francis said. "My boss asked me to shepherd this guy around. At the time I was a little upset because I was spending 12 hours a day doing research. Some time later, I got a phone call asking if I would interview at P&G."

Francis accepted a position in Cincinnati, Ohio, and spent his entire professional career with the company, where he earned more than 35 patents on his work.

" I used to feel guilty that I was having so much fun in my lab work and getting paid for it," he said.

Francis began working in dental research. His basic research played a role in the widespread adoption of fluoride therapies that resulted in a 70 to 80 percent reduction in the incidence of dental caries among children from 1967 to 1988. His further work provided the foundation for improving Crest toothpaste, more than doubling its cavity-fighting effectiveness and improving tartar control.

Subsequently, many countries around the world adopted fluoride therapies to improve dental health.

" It had a significant health effect," Francis said.

Francis wondered whether similar approaches could be used to strengthen bones. He and his colleagues developed a new class of compounds called disphosphonates (or bisphosphonates) that led to several drugs, including Didronel, used to treat Paget’s disease; Actonel for osteoporosis in post-menopausal women; and Osteonscan, used by radiologists to detect bone cancer.

In addition to his numerous patents, Francis was honored in 1994 with the American Chemical Society Award in Industrial Chemistry, in 1996 with the Perkin Medal of the American Section of the Society of Chemical Industry, and in 2000 as a "Hero of Chemistry" by the American Chemical Society.

Since retiring in 1993, Francis has kept busy consulting, traveling, and playing tennis, squash and golf. He looked forward to visiting Iowa again for the first time since receiving his PhD.

" I considered Iowa City my hometown for at least three straight years," he said. "I’m very honored to be receiving this award and very pleased. It is nice to go back."

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